ArticleJournal of virology2005
Anatomical and cellular requirements for the activation and migration of virus-specific CD8+ T cells to the brain during Theiler's virus infection.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- The Impact of Antigen Presentation on BBB Disruption and Neuroinflammation.Physiology (Bethesda, Md.) · 2026Review
- Virus-specific CD8 T cells rapidly populate and persist in skull bone marrow after brain infection.Research square · 2026Article
- Platelets, Thromboinflammation and Neurovascular Disease.Frontiers in immunology · 2022Review
- Glial activation positron emission tomography imaging in radiation treatment of breast cancer brain metastases.Physics and imaging in radiation oncology · 2022Review
- Conditional Silencing of H-2DJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Brain atrophy in picornavirus-infected FVB mice is dependent on the H-2DFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Gut dysbiosis and neuroimmune responses to brain infection with Theiler's murine encephalomyelitis virus.Scientific reports · 2017Article
- Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity.PLoS pathogens · 2012Article
- Transient peripheral immune response and central nervous system leaky compartmentalization in a viral model for multiple sclerosis.Brain pathology (Zurich, Switzerland) · 2010Article
- Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection.The American journal of pathology · 2009Article
- Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system.Virology · 2009Article
- Priming of CD8+ T cells during central nervous system infection with a murine coronavirus is strain dependent.Journal of virology · 2008Article
- NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain.Journal of neurovirology · 2008Article
- Role of dendritic cells in differential susceptibility to viral demyelinating disease.PLoS pathogens · 2007Article
- Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases.Genetics · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Theiler's murine encephalomyelitis virus (TMEV) infection of the brain induces a virus-specific CD8(+) T-cell response in genetically resistant mice. The peak of the immune response to the virus occurs 7 days after infection, with an immunodominant CD8(+) T-cell response against a VP2-derived capsid peptide in the context of the D(b) molecule. The process of activation of antigen-specific T cells that migrate to the brain in the TMEV model has not been defined. The site of antigenic challenge in the TMEV model is directly into the brain parenchyma, a site that is considered immune privileged. We investigated the hypothesis that antiviral CD8(+) T-cell responses are initiated in situ upon intracranial inoculation with TMEV. To determine whether a brain parenchymal antigen-presenting cell is responsible for the activation of virus-specific CD8(+) T cells, we evaluated the CD8(+) T-cell response to the VP2 peptide in bone marrow chimeras and mutant mice lacking peripheral lymphoid organs. The generation of the anti-TMEV CD8(+) T-cell response in the brain requires priming by a bone marrow-derived antigen-presenting cell and the presence of peripheral lymphoid organs. Although our results show that activation of TMEV-specific CD8(+) T cells occurs in the peripheral lymphoid compartment, they do not exclude the possibility that the immune response to TMEV is initiated by a brain-resident, bone marrow-derived, antigen-presenting cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.