Evidence map›Paper›PMID 15708992›Full record

ArticleJournal of virology2005

Identification and characterization of avihepadnaviruses isolated from exotic anseriformes maintained in captivity.

Haitao Guo, William S Mason, Carol E Aldrich, Jeffry R Saputelli, Darren S Miller, Allison R Jilbert, John E Newbold

Abstract read
In one paragraph

Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. Primary Duck Hepatocyte Culture and Duck Hepatitis B Virus Infection Model.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Evaluation of HBV-Like Circulation in Wild and Farm Animals from Brazil and Uruguay.International journal of environmental research and public health · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Animal models and the molecular biology of hepadnavirus infection.Cold Spring Harbor perspectives in medicine · 2015
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Haitao GuoFox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111, USA.
William S Mason
Carol E Aldrich
Jeffry R Saputelli
Darren S Miller
Allison R Jilbert
John E Newbold
Fox Chase Cancer Center · USSouth Australia Pathology · AUUniversity of Adelaide · AUUniversity of North Carolina at Chapel Hill · US

Funding

MOLECULAR BASIS FOR CHRONIC HEPADNAVIRAL INFECTIONSR01AI018641 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI MASON, WILLIAM · 1985 to 2009
$5.2M
NIAID NIH HHS AI-18641NIAID NIH HHS R01 AI018641
6 · The paper itself

Abstract

Five new hepadnaviruses were cloned from exotic ducks and geese, including the Chiloe wigeon, mandarin duck, puna teal, Orinoco sheldgoose, and ashy-headed sheldgoose. Sequence comparisons revealed that all but the mandarin duck viruses were closely related to existing isolates of duck hepatitis B virus (DHBV), while mandarin duck virus clones were closely related to Ross goose hepatitis B virus. Nonetheless, the S protein, core protein, and functional domains of the Pol protein were highly conserved in all of the new isolates. The Chiloe wigeon and puna teal hepatitis B viruses, the two new isolates most closely related to DHBV, also lacked an AUG start codon at the beginning of their X open reading frame (ORF). But as previously reported for the heron, Ross goose, and stork hepatitis B viruses, an AUG codon was found near the beginning of the X ORF of the mandarin duck, Orinoco, and ashy-headed sheldgoose viruses. In all of the new isolates, the X ORF ended with a stop codon at the same position. All of the cloned viruses replicated when transfected into the LMH line of chicken hepatoma cells. Significant differences between the new isolates and between these and previously reported isolates were detected in the pre-S domain of the viral envelope protein, which is believed to determine viral host range. Despite this, all of the new isolates were infectious for primary cultures of Pekin duck hepatocytes, and infectivity in young Pekin ducks was demonstrated for all but the ashy-headed sheldgoose isolate.

Indexed as

Amino Acid SequenceAnimalsAnimals, DomesticAnseriformesAvihepadnavirusBase SequenceCell LineChickensDNA, ViralDucksFemaleGeeseIn Situ HybridizationMaleMolecular Sequence DataPhylogenyDNA, ViralViral Proteins

Identifiers

PMID15708992
PMCPMC548436
OpenAlexW2141027664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.