ArticleBiochemical and biophysical research communications2005
Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice.
Article in Biochemical and biophysical research communications, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 69 citations in OpenAlex.
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- Leveraging on the genomics and immunopathology of SARS-CoV-2 for vaccines development: prospects and challenges.Human vaccines & immunotherapeutics · 2021Review
- Identification of SARS-CoV-2 Nucleocapsid and Spike T-Cell Epitopes for Assessing T-Cell Immunity.Journal of virology · 2021Article
- Single-Cell Analysis of Antigen-Specific CD8+ T-Cell Transcripts Reveals Profiles Specific to mRNA or Adjuvanted Protein Vaccines.Frontiers in immunology · 2021Article
- Challenges in the Development of a Vaccine Against COVID-19.Engineering (Beijing, China) · 2020Article
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- A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2.The FEBS journal · 2020Review
- A Testimony of the Surgent SARS-CoV-2 in the Immunological Panorama of the Human Host.Frontiers in cellular and infection microbiology · 2020Review
- COVID-19: The Emerging Immunopathological Determinants for Recovery or Death.Frontiers in microbiology · 2020Review
- Associations between immune-suppressive and stimulating drugs and novel COVID-19-a systematic review of current evidence.Ecancermedicalscience · 2020Review
- Defective Viral Particles Produced in Mast Cells Can Effectively Fight Against Lethal Influenza A Virus.Frontiers in microbiology · 2020Article
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- T cell-mediated immune response to respiratory coronaviruses.Immunologic research · 2014Review
- Understanding the T cell immune response in SARS coronavirus infection.Emerging microbes & infections · 2012Review
- Broad humoral and cellular immunity elicited by a bivalent DNA vaccine encoding HA and NP genes from an H5N1 virus.Viral immunology · 2011Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccination against the SARS-CoV infection is an attractive means to control the spread of viruses in public. In this study, we employed a DNA vaccine technology with the levamisole, our newly discovered chemical adjuvant, to generate Th1 type of response. To avoid the enhancement antibody issue, genes encoding the nucleocapsid, membrane, and envelope protein of SARS-CoV were cloned and their expressions in mammalian cells were determined. After the intramuscular introduction into animals, we observed that the constructs of the E, M, and N genes could induce high levels of specific antibodies, T cell proliferations, IFN-gamma, DTH responses, and in vivo cytotoxic T cells activities specifically against SARS-CoV antigens. The highest immune responses were generated by the construct encoding the nucleocapsid protein. The results suggest that the N, M, and E genes could be used as the targets to prevent SARS-CoV infection in the DNA vaccine development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.