ArticleMalaria journal2005
An AFLP-based genetic linkage map of Plasmodium chabaudi chabaudi.
Article in Malaria journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 39 citations in OpenAlex.
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- Genetic association of toxin production in the dinoflagellateMicrobial genomics · 2022Article
- Novel highly-multiplexed AmpliSeq targeted assay forFrontiers in cellular and infection microbiology · 2022Article
- High Proportion of Genome-Wide Homology and Increased PretreatmentAntimicrobial agents and chemotherapy · 2021Article
- Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross.Nature communications · 2019Article
- Amplified fragment length polymorphism: an adept technique for genome mapping, genetic differentiation, and intraspecific variation in protozoan parasites.Parasitology research · 2013Review
- Optimized protocols for improving the likelihood of cloning recombinant progeny from Plasmodium yoelii genetic crosses.Experimental parasitology · 2013Article
- Genetic mapping and coccidial parasites: past achievements and future prospects.Journal of biosciences · 2012Review
- Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Construction of a genetic map for Theileria parva: identification of hotspots of recombination.International journal for parasitology · 2011Article
- High recombination rates and hotspots in a Plasmodium falciparum genetic cross.Genome biology · 2011Article
- Limited polymorphism of the Plasmodium vivax merozoite surface protein 1 gene in isolates from Turkey.The American journal of tropical medicine and hygiene · 2010Article
- A major genetic locus in Trypanosoma brucei is a determinant of host pathology.PLoS neglected tropical diseases · 2009Article
- Hundreds of microsatellites for genotyping Plasmodium yoelii parasites.Molecular and biochemical parasitology · 2009Article
- Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map.Genome biology · 2008Article
- Linkage group selection: towards identifying genes controlling strain specific protective immunity in malaria.PloS one · 2007Article
- Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites.Molecular microbiology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlasmodium chabaudi chabaudi can be considered as a rodent model of human malaria parasites in the genetic analysis of important characters such as drug resistance and immunity. Despite the availability of some genome sequence data, an extensive genetic linkage map is needed for mapping the genes involved in certain traits.
methodsThe inheritance of 672 Amplified Fragment Length Polymorphism (AFLP) markers from two parental clones (AS and AJ) of P. c. chabaudi was determined in 28 independent recombinant progeny clones. These, AFLP markers and 42 previously mapped Restriction Fragment Length Polymorphism (RFLP) markers (used as chromosomal anchors) were organized into linkage groups using Map Manager software.
results614 AFLP markers formed linkage groups assigned to 10 of 14 chromosomes, and 12 other linkage groups not assigned to known chromosomes. The genetic length of the genome was estimated to be about 1676 centiMorgans (cM). The mean map unit size was estimated to be 13.7 kb/cM. This was slightly less then previous estimates for the human malaria parasite, Plasmodium falciparum
conclusionThe P. c. chabaudi genetic linkage map presented here is the most extensive and highly resolved so far available for this species. It can be used in conjunction with the genome databases of P. c chabaudi, P. falciparum and Plasmodium yoelii to identify genes underlying important phenotypes such as drug resistance and strain-specific immunity.
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