ArticleVirology journal2005
A new example of viral intein in Mimivirus.
Article in Virology journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Uncovering the Underlying Mechanisms Blocking Replication of Bluetongue Virus Serotype 26 (BTV-26) inBiomolecules · 2023Article
- The dynamic intein landscape of eukaryotes.Mobile DNA · 2018Article
- Intein Clustering Suggests Functional Importance in Different Domains of Life.Molecular biology and evolution · 2016Article
- Evolution of Eukaryotic DNA Polymerases via Interaction Between Cells and Large DNA Viruses.Journal of molecular evolution · 2015Article
- DNA transposons have colonized the genome of the giant virus Pandoravirus salinus.BMC biology · 2015Article
- Enigmatic distribution, evolution, and function of inteins.The Journal of biological chemistry · 2014Review
- Unveiling of the diversity of Prasinoviruses (Phycodnaviridae) in marine samples by using high-throughput sequencing analyses of PCR-amplified DNA polymerase and major capsid protein genes.Applied and environmental microbiology · 2014Article
- Inteins: Nature's Gift to Protein Chemists.Chemical science · 2014Article
- Gene invasion in distant eukaryotic lineages: discovery of mutually exclusive genetic elements reveals marine biodiversity.The ISME journal · 2013Article
- Prasinoviruses of the marine green alga Ostreococcus tauri are mainly species specific.Journal of virology · 2012Article
- Lateral gene exchanges shape the genomes of amoeba-resisting microorganisms.Frontiers in cellular and infection microbiology · 2012Review
- Giant virus with a remarkable complement of genes infects marine zooplankton.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Remarkable sequence similarity between the dinoflagellate-infecting marine girus and the terrestrial pathogen African swine fever virus.Virology journal · 2009Article
- Marine mimivirus relatives are probably large algal viruses.Virology journal · 2008Article
- Taxonomic distribution of large DNA viruses in the sea.Genome biology · 2008Article
- Multiple, non-allelic, intein-coding sequences in eukaryotic RNA polymerase genes.BMC biology · 2006Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInteins are "protein introns" that remove themselves from their host proteins through an autocatalytic protein-splicing. After their discovery, inteins have been quickly identified in all domains of life, but only once to date in the genome of a eukaryote-infecting virus.
resultsHere we report the identification and bioinformatics characterization of an intein in the DNA polymerase PolB gene of amoeba infecting Mimivirus, the largest known double-stranded DNA virus, the origin of which has been proposed to predate the emergence of eukaryotes. Mimivirus intein exhibits canonical sequence motifs and clearly belongs to a subclass of archaeal inteins always found in the same location of PolB genes. On the other hand, the Mimivirus PolB is most similar to eukaryotic Poldelta sequences.
conclusionsThe intriguing association of an extremophilic archaeal-type intein with a mesophilic eukaryotic-like PolB in Mimivirus is consistent with the hypothesis that DNA viruses might have been the central reservoir of inteins throughout the course of evolution.
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