ArticleVirology journal2005
Replicative homeostasis: a fundamental mechanism mediating selective viral replication and escape mutation.
Article in Virology journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Molecular and Replication Dynamic Profiling of Regionally ImportantAnimals : an open access journal from MDPI · 2026Article
- Prevalence of pretreatment HIV drug resistance in West African and Southeast Asian countries.The Journal of antimicrobial chemotherapy · 2019Article
- The effects of hepatitis C virus core protein on the expression of miR-122 in vitro.Virology journal · 2013Article
- Very low viral load (VLVL) relapse following treatment of naïve patients with chronic hepatitis C.Digestive diseases and sciences · 2012Article
- Rapid evolution of pandemic noroviruses of the GII.4 lineage.PLoS pathogens · 2010Article
- Genetic characterization of hepatitis B virus in peripheral blood leukocytes: evidence for selection and compartmentalization of viral variants with the immune escape G145R mutation.Journal of virology · 2009Article
- Correlation between pre-treatment quasispecies complexity and treatment outcome in chronic HCV genotype 3a.Virology journal · 2008Article
- Replicative homeostasis III: implications for antiviral therapy and mechanisms of response and non-response.Virology journal · 2007Article
- Treatment of chronic HCV infection in special populations.International journal of medical sciences · 2006Article
- Replicative homeostasis II: influence of polymerase fidelity on RNA virus quasispecies biology: implications for immune recognition, viral autoimmunity and other "virus receptor" diseases.Virology journal · 2005Review
- Pleiotropic mechanisms of virus survival and persistence.Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C (HCV), hepatitis B (HBV), the human immunodeficiency viruses (HIV), and other viruses that replicate via RNA intermediaries, cause an enormous burden of disease and premature death worldwide. These viruses circulate within infected hosts as vast populations of closely related, but genetically diverse, molecules known as "quasispecies". The mechanism(s) by which this extreme genetic and antigenic diversity is stably maintained are unclear, but are fundamental to understanding viral persistence and pathobiology. The persistence of HCV, an RNA virus, is especially problematic and HCV stability, maintained despite rapid genomic mutation, is highly paradoxical. This paper presents the hypothesis, and evidence, that viruses capable of persistent infection autoregulate replication and the likely mechanism mediating autoregulation - Replicative Homeostasis - is described. Replicative homeostasis causes formation of stable, but highly reactive, equilibria that drive quasispecies expansion and generates escape mutation. Replicative homeostasis explains both viral kinetics and the enigma of RNA quasispecies stability and provides a rational, mechanistic basis for all observed viral behaviours and host responses. More importantly, this paradigm has specific therapeutic implication and defines, precisely, new approaches to antiviral therapy. Replicative homeostasis may also modulate cellular gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.