ArticleEndocrinology2005
Mouse GnRH receptor gene expression is mediated by the LHX3 homeodomain protein.
Article in Endocrinology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Pituitary Tumors and Immortalized Cell Lines Generated by Cre-Inducible Expression of SV40 T Antigen.Endocrinology · 2021Article
- Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes.Molecular and cellular endocrinology · 2021Article
- Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines.Reproductive biology and endocrinology : RB&E · 2017Article
- Divergent activity of the gonadotropin-releasing hormone receptor gene promoter among genetic lines of pigs is partially conferred by nuclear factor (NF)-B, specificity protein (SP)1-like and GATA-4 binding sites.Reproductive biology and endocrinology : RB&E · 2016Article
- Fshb-iCre mice are efficient and specific Cre deleters for the gonadotrope lineage.Molecular and cellular endocrinology · 2016Article
- Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?Molecular endocrinology (Baltimore, Md.) · 2015Review
- Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Activity of the porcine gonadotropin-releasing hormone receptor gene promoter is partially conferred by a distal gonadotrope specific element (GSE) within an upstream enhancing region, two proximal GSEs and a retinoid X receptor binding site.Reproductive biology and endocrinology : RB&E · 2015Article
- Combined pituitary hormone deficiency: current and future status.Journal of endocrinological investigation · 2015Review
- Cell-specific actions of a human LHX3 gene enhancer during pituitary and spinal cord development.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Gene dosage of Otx2 is important for fertility in male mice.Molecular and cellular endocrinology · 2013Article
- Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Developmental analysis and influence of genetic background on the Lhx3 W227ter mouse model of combined pituitary hormone deficiency disease.Endocrinology · 2013Article
- LHX3 interacts with inhibitor of histone acetyltransferase complex subunits LANP and TAF-1β to modulate pituitary gene regulation.PloS one · 2013Article
- GATA2-induced silencing and LIM-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat GnRH receptor gene.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Mechanisms underlying the tissue-specific and regulated activity of the Gnrhr promoter in mammals.Frontiers in endocrinology · 2012Article
- The role of homeodomain transcription factors in heritable pituitary disease.Nature reviews. Endocrinology · 2011Review
- Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Appropriate expression of GnRH receptor (GnRHR) is necessary for the correct regulation of the gonadotropins, LH and FSH, by GnRH. GnRHR is primarily expressed in the gonadotrope cells of the anterior pituitary, and a number of regulatory elements important for both basal and hormonal regulation of the gene have been identified. Using the gonadotrope-derived cell line, alpha T3-1, that endogenously expresses GnRHR, we have identified an ATTA element located at -298 relative to the transcriptional start site that is essential for basal expression of the GnRHR gene. LHX3, a member of the LIM homeodomain family, binds the -298 ATTA site in vitro as well as to the endogenous GnRHR promoter in vivo. Additionally, LHX3 specifically activates through this -298 ATTA site in transient transfection assays. LHX3 is essential for pituitary development and has been implicated in the regulation of a number of pituitary specific genes; however, this is the first report identifying its role in the regulation of GnRHR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.