ArticleProceedings. Biological sciences2005
Rates and patterns of gene duplication and loss in the human genome.
Article in Proceedings. Biological sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 73 citations in OpenAlex.
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- Protein-protein binding selectivity and network topology constrain global and local properties of interface binding networks.Scientific reports · 2017Article
- Novel Genomic and Evolutionary Perspective of Cyanobacterial tRNAs.Frontiers in genetics · 2017Article
- Inferring gene duplications, transfers and losses can be done in a discrete framework.Journal of mathematical biology · 2016Article
- A generalized birth and death process for modeling the fates of gene duplication.BMC evolutionary biology · 2015Article
- Review
- Early evolutionary history and genomic features of gene duplicates in the human genome.BMC genomics · 2015Article
- Systematic Discovery of Human Gene Function and Principles of Modular Organization through Phylogenetic Profiling.Cell reports · 2015Article
- Restriction and recruitment-gene duplication and the origin and evolution of snake venom toxins.Genome biology and evolution · 2014Article
- Estimation for general birth-death processes.Journal of the American Statistical Association · 2014Article
- DrML: probabilistic modeling of gene duplications.Journal of computational biology : a journal of computational molecular cell biology · 2014Article
- Copy-number changes in evolution: rates, fitness effects and adaptive significance.Frontiers in genetics · 2013Review
- Probabilistic orthology analysis of the ATP-binding cassette transporters: implications for the development of multiple drug resistance phenotype.Drug metabolism and disposition: the biological fate of chemicals · 2012Article
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- Evolution of orthologous tandemly arrayed gene clusters.BMC bioinformatics · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene duplication has certainly played a major role in structuring vertebrate genomes but the extent and nature of the duplication events involved remains controversial. A recent study identified two major episodes of gene duplication: one episode of putative genome duplication ca. 500 Myr ago and a more recent gene-family expansion attributed to segmental or tandem duplications. We confirm this pattern using methods not reliant on molecular clocks for individual gene families. However, analysis of a simple model of the birth-death process suggests that the apparent recent episode of duplication is an artefact of the birth-death process. We show that a constant-rate birth-death model is appropriate for gene duplication data, allowing us to estimate the rate of gene duplication and loss in the vertebrate genome over the last 200 Myr (0.00115 and 0.00740 Myr(-1) lineage(-1), respectively). Finally, we show that increasing rates of gene loss reduce the impact of a genome-wide duplication event on the distribution of gene duplications through time.
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