ArticleHuman brain mapping2005
Mapping structural differences of the corpus callosum in individuals with 18q deletions using targetless regional spatial normalization.
Article in Human brain mapping, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00227253 (The Chromosome 18 Clinical Research Center), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Chromosome 18 Clinical Research Center
Who cites it
23 citing papers in PubMed.
- The effect of age and microstructural white matter integrity on lap time variation and fast-paced walking speed.Brain imaging and behavior · 2016Article
- Physical activity, inflammation, and volume of the aging brain.Neuroscience · 2014Article
- Brain growth rate abnormalities visualized in adolescents with autism.Human brain mapping · 2013Article
- Unbiased tensor-based morphometry: improved robustness and sample size estimates for Alzheimer's disease clinical trials.NeuroImage · 2013Article
- Article
- Genetic contributions to the midsagittal area of the corpus callosum.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2012Article
- Fractional anisotropy of water diffusion in cerebral white matter across the lifespan.Neurobiology of aging · 2012Article
- Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies.Journal of neurovirology · 2011Article
- Initial results on development and application of statistical atlas of femoral cartilage in osteoarthritis to determine sex differences in structure: data from the Osteoarthritis Initiative.Journal of magnetic resonance imaging : JMRI · 2011Article
- Comparing 3 T and 1.5 T MRI for tracking Alzheimer's disease progression with tensor-based morphometry.Human brain mapping · 2010Article
- Development of structural MR brain imaging protocols to study genetics and maturation.Methods (San Diego, Calif.) · 2010Article
- Processing speed is correlated with cerebral health markers in the frontal lobes as quantified by neuroimaging.NeuroImage · 2010Article
- Can structural MRI indices of cerebral integrity track cognitive trends in executive control function during normal maturation and adulthood?Human brain mapping · 2009Article
- Article
- Loss of cerebral white matter structural integrity tracks the gray matter metabolic decline in normal aging.NeuroImage · 2009Article
- Detecting brain growth patterns in normal children using tensor-based morphometry.Human brain mapping · 2009Article
- Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects.NeuroImage · 2008Article
- 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry.NeuroImage · 2008Article
- Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer's disease.NeuroImage · 2008Article
- Structural consequences of diffuse traumatic brain injury: a large deformation tensor-based morphometry study.NeuroImage · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Individuals with a constitutional chromosome abnormality consisting of a deletion of a portion of the long arm of chromosome 18 (18q-) have a high incidence ( approximately 95%) of dysmyelination. Neuroradiologic findings in affected children report a smaller corpus callosum, but this finding has not been quantified. This is in part due to the large intersubject variability of the corpus callosum size and shape and the small number of subjects with 18q-, which leads to low statistical power for comparison with typically developing children. An analysis method called targetless spatial normalization (TSN) was used to improve the sensitivity of statistical testing. TSN converges all images in a group into what is referred as group common space. The group common space conserves common shape, size, and orientation while reducing intragroup variability. TSN in conjunction with a Witelson vertical partitioning scheme was used to assess differences in corpus callosum size between 12 children with 18q- and 12 age-matched normal controls. Significant global and regional differences in corpus callosum size were seen. The 18q- group showed an overall smaller (25%) corpus callosum (P < 10(-7)), even after correction for differences in brain size. Regionally, the posterior portions of corpus callosum (posterior midbody, isthmus, and splenium), which contain heavily myelinated fibers, were found to be 25% smaller in the population with 18q-.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.