ArticleJournal of cancer research and clinical oncology2005
Glucocorticoids induce G1 cell cycle arrest in human neoplastic thymic epithelial cells.
Article in Journal of cancer research and clinical oncology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Efficacy and safety of high-dose prednisone for patients with advanced thymoma: a retrospective study.Journal of thoracic disease · 2026Article
- Dexamethasone promotes neutrophil ROS-mediated tumor killing through the glucocorticoid receptor.Oncogene · 2026Article
- Neoadjuvant Glucocorticoids Facilitate Resection in Advanced B-Type Thymomas: A Propensity-Matched Analysis of Surgical and Survival Outcomes.Thoracic cancer · 2026Article
- Treatment of thymoma with low-dose glucocorticoids before surgery for significant tumor shrinkage: A case report.World journal of clinical cases · 2025Article
- Methylprednisolone pulse versus docetaxel in recurrent thymoma with myasthenia gravis.Frontiers in neurology · 2025Article
- Current immunotherapy for thymic epithelial tumors: a narrative review.Mediastinum (Hong Kong, China) · 2024Review
- The Never-Ending History of Octreotide in Thymic Tumors: A Vintage or A Contemporary Drug?Cancers · 2022Review
- Single-center evaluation of prognostic factors for thymoma treated by surgery: a retrospective study.Journal of cardiothoracic surgery · 2021Article
- Thymectomy during Myasthenic Crisis under Artificial Respiration.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2019Article
- Effects of dexamethasone on C6 cell proliferation, migration and invasion through the upregulation of AQP1.Oncology letters · 2018Article
- Metastatic Thymoma-Associated Myasthenia Gravis: Favorable Response to Steroid Pulse Therapy Plus Immunosuppressive Agent.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Successful treatment of advanced thymic carcinoma with lymph node and pleural metastases: A case report.Molecular and clinical oncology · 2016Article
- Clear cell carcinoma originating from ectopic thymus.General thoracic and cardiovascular surgery · 2009Article
- Rapid regression of stage IVb invasive thymoma under palliative corticosteroid administration.General thoracic and cardiovascular surgery · 2007Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGlucocorticoids exert anti-proliferative effects in various cell types and have long been known to induce apoptosis in thymocytes. Although a few reports have described the regression of human thymoma with glucocorticoid therapy, its effects on neoplastic thymic epithelial cells (TECs) have not been reported. In the present study, we investigated glucocorticoid receptor (GR) expression on neoplastic TECs and the effects of glucocorticoids in vitro on the cell cycle progression of tumor cells. PATIENTS AND
methodsThymoma specimens were obtained during surgery from 21 patients. Three of the specimens with glucocorticoid therapy were examined using the TdT-mediated dUTP-biotin nick-end labeling method. Primary tumor specimens from ten untreated thymomas were examined for GR expression by immunohistochemistry. Isolated neoplastic TECs from the remaining eight untreated thymomas were examined using immunohistochemistry, flow cytometric and cell cycle analysis.
resultsGR are expressed on neoplastic TECs as well as on non-neoplastic thymocytes in thymomas, regardless of WHO histological classification. Glucocorticoids caused an accumulation of TEC in G0/G1 phase in all cases examined (n = 6), and also induced apoptosis in the three with the lowest levels of Bcl-2 expression.
conclusionsOur results indicate that neoplastic TECs express GR and that glucocorticoids directly suppress their in vitro proliferation.
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