ArticlePlanta2005
Fumonisin B1, a sphingoid toxin, is a potent inhibitor of the plasma membrane H+-ATPase.
Article in Planta, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Molecular tipping points in plant cell surface HQuantitative plant biology · 2025Review
- Organized Disassembly of Photosynthesis During Programmed Cell Death Mediated By Long Chain Bases.Scientific reports · 2020Article
- Sphingolipid Effects on the Plasma Membrane Produced by Addition of Fumonisin B1 to Maize Embryos.Plants (Basel, Switzerland) · 2020Article
- Dark septate endophytic fungi increase the activity of proton pumps, efficiency ofBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Genetic analysis of cob resistance to F. verticillioides: another step towards the protection of maize from ear rot.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Environmental pH modulates transcriptomic responses in the fungus Fusarium sp. associated with KSHB Euwallacea sp. near fornicatus.BMC genomics · 2018Article
- Plant lipid environment and membrane enzymes: the case of the plasma membrane H+-ATPase.Plant cell reports · 2015Review
- Rice Sheath Rot: An Emerging Ubiquitous Destructive Disease Complex.Frontiers in plant science · 2015Review
- Early carbon mobilization and radicle protrusion in maize germination.Journal of experimental botany · 2012Article
- Article
- The role of the plasma membrane H+-ATPase in plant-microbe interactions.Molecular plant · 2011Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fumonisin B(1) (FB(1)) is an amphipathic toxin produced by the pathogenic fungus Fusarium verticillioides which causes stem, root and ear rot in maize (Zea mays L.). In this work, we studied the action of FB(1) on the plasma membrane H(+)-ATPase (EC 3.6.1.34) from germinating maize embryos, and on the fluidity and lipid peroxidation of these membranes. In maize embryos the toxin at 40 microM inhibited root elongation by 50% and at 30 microM decreased medium acidification by about 80%. Irrespective of the presence and absence of FB(1), the H(+)-ATPase in plasma membrane vesicles exhibited non-hyperbolic saturation kinetics by ATPH-Mg, with Hill number of 0.67. Initial velocity studies revealed that FB(1) is a total uncompetitive inhibitor of this enzyme with an inhibition constant value of 17.5+/-1 microM. Thus FB(1) decreased V(max) and increased the apparent affinity of the enzyme for ATP-Mg to the same extent. Although FB(1) increased the fluidity at the hydrophobic region of the membrane, no correlation was found with its effect on enzyme activity, since both effects showed different FB(1)-concentration dependence. Peroxidation of membrane lipids was not affected by the toxin. Our results suggest that, under in vivo conditions, the plasma membrane H(+)-ATPase is a potentially important target of the toxin, as it is inhibited not only by FB(1) but also by its structural analogs, the sphingoid intermediates, which accumulate upon the inhibition of sphinganine N-acyltransferase by this toxin.
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