ReviewGene therapy2005
Gene therapy progress and prospects: novel gene therapy approaches for AIDS.
Review in Gene therapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Inhibition of HIV-1 Viral Infection by an Engineered CRISPR Csy4 RNA Endoribonuclease.PloS one · 2015Article
- A suicide gene approach using the human pro-apoptotic protein tBid inhibits HIV-1 replication.BMC biotechnology · 2011Article
- Therapeutic opportunities of small interfering RNA.Fundamental & clinical pharmacology · 2009Review
- Femtosecond laser treatment enhances DNA transfection efficiency in vivo.Journal of biomedical science · 2009Article
- Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model.Gene therapy · 2009Article
- Resistance to human immunodeficiency virus type 1 (HIV-1) generated by lentivirus vector-mediated delivery of the CCR5{Delta}32 gene despite detectable expression of the HIV-1 co-receptors.The Journal of general virology · 2008Article
- Lentiviral vector design for multiple shRNA expression and durable HIV-1 inhibition.Molecular therapy : the journal of the American Society of Gene Therapy · 2008Article
- Random screening for dominant-negative mutants of the cytomegalovirus nuclear egress protein M50.Journal of virology · 2007Article
- Gene therapy progress and prospects: RNA aptamers.Gene therapy · 2007Review
- Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity.Blood · 2006Article
- Inhibition of human immunodeficiency virus type 1 by RNA interference using long-hairpin RNA.Gene therapy · 2006Article
- T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery.Gene therapy · 2006Article
- Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus.Gene therapy · 2006Article
- An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors.Chembiochem : a European journal of chemical biology · 2006Article
- Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay.Molecular and cellular biology · 2006Article
- Targeted delivery of siRNA.Journal of biomedicine & biotechnology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus (HIV), kills millions worldwide every year. Vaccines against HIV still seem a distant promise. Pharmaceutical treatments exist, but these are not always effective, and there is increasing prevalence of viral strains with multidrug resistance. Highly active antiretroviral therapy (HAART) consists of inhibitors of viral enzymes (reverse transcriptase (RT) and protease). Gene therapy, first introduced as intracellular immunization, may offer hopes for new treatments to be used alone, or in conjunction with, conventional small molecule drugs. Gene therapy approaches against HIV-1, including suicide genes, RNA-based technology, dominant negative viral proteins, intracellular antibodies, intrakines, and peptides, are the subject of this review.
Indexed as
Identifiers
15703764What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.