ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Bladder p75Life (Basel, Switzerland) · 2025Article
- Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?Neural regeneration research · 2024Review
- Review
- proNGF Involvement in the Adult Neurogenesis Dysfunction in Alzheimer's Disease.International journal of molecular sciences · 2021Article
- c-Jun N-terminal Kinase Mediates Ligand-independent p75Neuroscience · 2021Article
- The p75FEBS open bio · 2021Article
- Saikosaponin-d impedes hippocampal neurogenesis and causes cognitive deficits by inhibiting the survival of neural stem/progenitor cells via neurotrophin receptor signaling in mice.Clinical and translational medicine · 2020Article
- Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Article
- proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing.Molecular brain · 2018Article
- Moringin Induces Neural Differentiation in the Stem Cell of the Human Periodontal Ligament.Scientific reports · 2018Article
- p75 neurotrophin receptor regulates differential mineralization of rat ectomesenchymal stem cells.Cell proliferation · 2017Article
- A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.Human molecular genetics · 2016Article
- Imbalance of the Nerve Growth Factor and Its Precursor: Implication in Diabetic Retinopathy.Journal of clinical & experimental ophthalmology · 2015Article
- Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Cerebellar Purkinje cell p75 neurotrophin receptor and autistic behavior.Translational psychiatry · 2014Article
- Nerve growth factor in diabetic retinopathy: beyond neurons.Expert review of ophthalmology · 2014Article
- Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats.Diabetologia · 2013Article
- Nerve growth factor-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation.Molecular and cellular biology · 2012Article
- p75(NTR) expression and nuclear localization of p75(NTR) intracellular domain in spiral ganglion Schwann cells following deafness correlate with cell proliferation.Molecular and cellular neurosciences · 2011Article
- A nuclear variant of ErbB3 receptor tyrosine kinase regulates ezrin distribution and Schwann cell myelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intracellular domain of the p75 neurotrophin receptor (p75ICD) can be released by gamma-secretase in response to the previous activation of alpha-secretase by phorbol esters. However, ligand-dependent release of p75ICD has yet to be described. We show here that nerve growth factor can induce the release of p75ICD and facilitate its translocation to the nucleus in a gamma-secretase-dependent manner. This effect was observed in RN22 schwannoma cells cultured under serum-free conditions, as well as in Schwann cells, and it was mimicked by other neurotrophins, such as brain-derived neurotrophic factor or neurotrophin-3. Unlike other known examples of regulated intramembrane proteolysis, ligand-dependent release of p75ICD did not need the previous activation of alpha-secretase. These results suggest that nuclear translocation of p75ICD may represent a novel neurotrophin-mediated signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.