ArticleMolecular biology of the cell2005
A member of the sugar transporter family, Stl1p is the glycerol/H+ symporter in Saccharomyces cerevisiae.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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89 citing papers in PubMed, 221 citations in OpenAlex.
- Advances in glycerol metabolism comprehension in yeasts: from regulation to metabolic engineering strategies.World journal of microbiology & biotechnology · 2026Review
- Characterization of three glycerol transporters with broad sugar specificities from Aspergillus niger.Applied microbiology and biotechnology · 2026Article
- A Semi-Quantitative Yeast Complementation Platform for Characterizing Urea and Ammonia Transport by Membrane Channels.Current protocols · 2026Article
- Yeast Stress Response to Synthetic Constructs.ACS synthetic biology · 2026Review
- Stress-Induced Cross-Protection and Combined Stress Responses in Extremotolerant Black Yeasts.Journal of fungi (Basel, Switzerland) · 2026Article
- Unravelling the Molecular Responses of the YeastInternational journal of molecular sciences · 2025Article
- Arabitol production: influence of acid and salt stress on glycerol fermentation by Komagataella pastoris, Scheffersomyces stipitis, and Pichia kluyveri in a batch system.Biotechnology letters · 2025Article
- A new yeast strain for valorisation of vinasse, a rum distillery waste product.Biotechnology for biofuels and bioproducts · 2025Article
- A four eigen-phase model of multi-omics unveils new insights into yeast metabolic cycle.NAR genomics and bioinformatics · 2025Article
- Enhanced multistress tolerance ofMicrobiology spectrum · 2025Article
- Glycerol bioconversion to biofuel and value-added products by yeasts.FEMS yeast research · 2025Review
- Engineering of xylose metabolic pathways in Rhodotorula toruloides for sustainable biomanufacturing.FEMS yeast research · 2025Review
- The physiology of an engineered Saccharomyces cerevisiae strain that carries both an improved glycerol-3-phosphate and the synthetic dihydroxyacetone pathway for glycerol utilization.FEMS yeast research · 2025Article
- Preparation of Multifunctional Nano-Protectants for High-Efficiency Green Control of Anthracnose.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Black yeasts in hypersaline conditions.Applied microbiology and biotechnology · 2024Review
- Evolution and functional diversification of yeast sugar transporters.Essays in biochemistry · 2023Article
- Multiplex modification of Yarrowia lipolytica for enhanced erythritol biosynthesis from glycerol through modularized metabolic engineering.Bioprocess and biosystems engineering · 2023Article
- Article
- Identification of an l-Arabitol Transporter fromBiomolecules · 2023Article
- Article
29 more citing papers are in PubMed but not listed here.
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8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycerol and other polyols are used as osmoprotectants by many organisms. Several yeasts and other fungi can take up glycerol by proton symport. To identify genes involved in active glycerol uptake in Saccharomyces cerevisiae we screened a deletion mutant collection comprising 321 genes encoding proteins with 6 or more predicted transmembrane domains for impaired growth on glycerol medium. Deletion of STL1, which encodes a member of the sugar transporter family, eliminates active glycerol transport. Stl1p is present in the plasma membrane in S. cerevisiae during conditions where glycerol symport is functional. Both the Stl1 protein and the active glycerol transport are subject to glucose-induced inactivation, following identical patterns. Furthermore, the Stl1 protein and the glycerol symporter activity are strongly but transiently induced when cells are subjected to osmotic shock. STL1 was heterologously expressed in Schizosaccharomyces pombe, a yeast that does not contain its own active glycerol transport system. In S. pombe, STL1 conferred the ability to take up glycerol against a concentration gradient in a proton motive force-dependent manner. We conclude that the glycerol proton symporter in S. cerevisiae is encoded by STL1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.