ArticleEukaryotic cell2005
Chromosomal translocation and segmental duplication in Cryptococcus neoformans.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 98 citations in OpenAlex.
- Chromosomal Replication, Translocation and Recombination as Putative Events in the Diversification of VertebrateInternational journal of molecular sciences · 2026Article
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- Genome-wide analysis of theFrontiers in plant science · 2026Article
- Genome-wide analysis of the CsAP2/ERF gene family of sweet orange (Citrus sinensis) and joint analysis of transcriptional metabolism under salt stress.Annals of botany · 2025Article
- Article
- Dispensable genome and segmental duplications drive the genome plasticity inFrontiers in fungal biology · 2025Article
- Complete genome of the Medicago anthracnose fungus,Microbial genomics · 2024Article
- Genome-Wide Identification of the Alfin-like Gene Family in Cotton (Plants (Basel, Switzerland) · 2024Article
- Comparative genomics of the closely related fungal genera Cryptococcus and Kwoniella reveals karyotype dynamics and suggests evolutionary mechanisms of pathogenesis.PLoS biology · 2024Article
- Comparative genomics ofbioRxiv : the preprint server for biology · 2024Article
- Genome-Wide Analysis of thePlants (Basel, Switzerland) · 2023Article
- Genomic identification of cottonFrontiers in plant science · 2023Article
- Review
- Application of an optimized annotation pipeline to the Cryptococcus deuterogattii genome reveals dynamic primary metabolic gene clusters and genomic impact of RNAi loss.G3 (Bethesda, Md.) · 2021Article
- Whole-genome characterization of Rosa chinensis AP2/ERF transcription factors and analysis of negative regulator RcDREB2B in Arabidopsis.BMC genomics · 2021Article
- Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans.PLoS genetics · 2021Article
- Genome Wild Analysis and Molecular Understanding of the Aquaporin Diversity in Olive Trees (International journal of molecular sciences · 2020Article
- Genome-Wide Characterization and Analysis ofInternational journal of molecular sciences · 2020Article
- Genome-Wide Study of the GATL Gene Family inGenes · 2020Article
- Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Large chromosomal events such as translocations and segmental duplications enable rapid adaptation to new environments. Here we marshal genomic, genetic, meiotic mapping, and physical evidence to demonstrate that a chromosomal translocation and segmental duplication occurred during construction of a congenic strain pair in the fungal human pathogen Cryptococcus neoformans. Two chromosomes underwent telomere-telomere fusion, generating a dicentric chromosome that broke to produce a chromosomal translocation, forming two novel chromosomes sharing a large segmental duplication. The duplication spans 62,872 identical nucleotides and generated a second copy of 22 predicted genes, and we hypothesize that this event may have occurred during meiosis. Gene disruption studies of one embedded gene (SMG1) corroborate that this region is duplicated in an otherwise haploid genome. These findings resolve a genome project assembly anomaly and illustrate an example of rapid genome evolution in a fungal genome rich in repetitive elements.
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