ArticleEukaryotic cell2005
Coevolution of cyclin Pcl5 and its substrate Gcn4.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Regulation of heme utilization and homeostasis in Candida albicans.PLoS genetics · 2022Article
- Filament Negative RegulatorJournal of fungi (Basel, Switzerland) · 2022Article
- From Jekyll to Hyde: The Yeast-Hyphal Transition ofPathogens (Basel, Switzerland) · 2021Review
- THR1 mediates GCN4 and CDC4 to link morphogenesis with nutrient sensing and the stress response in Candida albicans.International journal of molecular medicine · 2018Article
- A High-ThroughputmSphere · 2018Article
- A Global Analysis of Kinase Function inFrontiers in cellular and infection microbiology · 2018Article
- A new rapid and efficient system with dominant selection developed to inactivate and conditionally express genes in Candida albicans.Current genetics · 2016Article
- Article
- Evolution of bacterial protein-tyrosine kinases and their relaxed specificity toward substrates.Genome biology and evolution · 2014Article
- Unreported intrinsic disorder in proteins: Building connections to the literature on IDPs.Intrinsically disordered proteins · 2014Article
- Mutual cross talk between the regulators Hac1 of the unfolded protein response and Gcn4 of the general amino acid control of Saccharomyces cerevisiae.Eukaryotic cell · 2013Article
- Neddylation and CAND1 independently stimulate SCF ubiquitin ligase activity in Candida albicans.Eukaryotic cell · 2012Article
- Candida albicans cyclin Clb4 carries S-phase cyclin activity.Eukaryotic cell · 2010Article
- Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans.Eukaryotic cell · 2009Article
- Degradation of Saccharomyces cerevisiae transcription factor Gcn4 requires a C-terminal nuclear localization signal in the cyclin Pcl5.Eukaryotic cell · 2009Article
- Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation.Molecular and cellular biology · 2008Article
- Global role of the protein kinase Gcn2 in the human pathogen Candida albicans.Eukaryotic cell · 2005Article
- Role for the SCFCDC4 ubiquitin ligase in Candida albicans morphogenesis.Molecular biology of the cell · 2005Article
- Regulation of themSphereArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gcn4, a transcription factor that plays a key role in the response of Saccharomyces cerevisiae to amino acid starvation, is regulated at both the levels of translation and of protein stability. Regulated degradation of Gcn4 depends on its phosphorylation by the cyclin-dependent kinase Pho85, in conjunction with the cyclin Pcl5. The pathogenic yeast Candida albicans contains a functional homolog of Gcn4, which is involved in amino acid metabolism, as well as in the regulation of filamentous growth in response to starvation. Here, we show that C. albicans Gcn4 (CaGcn4) is rapidly degraded and that this degradation depends on a Pho85 cyclin homolog, CaPcl5. The regulatory loop that includes Gcn4 and Pcl5 is conserved in C. albicans: like in S. cerevisiae, CaPcl5 is transcriptionally induced by CaGcn4 and is required for CaGcn4 degradation. However, the proteins have coevolved so that there is no cross-recognition between the proteins from the two species: phosphorylation-dependent degradation of CaGcn4 occurs only in the presence of CaPcl5, and S. cerevisiae Gcn4 (ScGcn4) requires ScPcl5 for its degradation. Phenotypic analysis of the Capcl5 mutant indicates that CaPcl5 also modulates the filamentous response of C. albicans in amino acid-rich media.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.