ArticleNucleic acids research2005
A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Deciphering the Genetic Diversity of Landraces With High-Throughput SNP Genotyping of DNA Bulks: Methodology and Application to the Maize 50k Array.Frontiers in plant science · 2020Article
- Comparison of genotyping using pooled DNA samples (allelotyping) and individual genotyping using the affymetrix genome-wide human SNP array 6.0.BMC genomics · 2013Article
- Malic enzyme gene polymorphism is associated with responsiveness in circulating parathyroid hormone after long-term calcium supplementation.The journal of nutrition, health & aging · 2012Article
- Article
- Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samples.PLoS genetics · 2010Article
- A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples.Behavior genetics · 2010Article
- The role of genetic variation near interferon-kappa in systemic lupus erythematosus.Journal of biomedicine & biotechnology · 2010Article
- Validation of pooled genotyping on the Affymetrix 500 k and SNP6.0 genotyping platforms using the polynomial-based probe-specific correction.BMC genetics · 2009Article
- Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.Human molecular genetics · 2009Article
- The SNPMaP package for R: a framework for genome-wide association using DNA pooling on microarrays.Bioinformatics (Oxford, England) · 2009Article
- A comparison of association statistics between pooled and individual genotypes.Human heredity · 2009Article
- Microarray-based estimation of SNP allele-frequency in pooled DNA using the Langmuir kinetic model.BMC genomics · 2008Article
- Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children.Molecular psychiatry · 2008Article
- The nature of nurture: a genomewide association scan for family chaos.Behavior genetics · 2008Article
- Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays.Genes, brain, and behavior · 2008Article
- MPDA: microarray pooled DNA analyzer.BMC bioinformatics · 2008Article
- Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies.BMC genomics · 2007Article
- Allelotyping of pooled DNA with 250 K SNP microarrays.BMC genomics · 2007Article
- A generic research paradigm for identification and validation of early molecular diagnostics and new therapeutics in common disorders.Molecular diagnosis & therapy · 2007Review
- Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies.American journal of human genetics · 2007Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Analysing pooled DNA on microarrays is an efficient way to genotype hundreds of individuals for thousands of markers for genome-wide association. Although direct comparison of case and control fluorescence scores is possible, correction for differential hybridization of alleles is important, particularly for rare single nucleotide polymorphisms. Such correction relies on heterozygous fluorescence scores and requires the genotyping of hundreds of individuals to obtain sufficient estimates of the correction factor, completely negating any benefit gained by pooling samples. We explore the effect of differential hybridization on test statistics and provide a solution to this problem in the form of a central resource for the accumulation of heterozygous fluorescence scores, allowing accurate allele frequency estimation at no extra cost.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.