ArticleMolecular and cellular biology1992
Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Genome-wide association studies in Alzheimer's disease.Human molecular genetics · 2009Review
- CGI: Java software for mapping and visualizing data from array-based comparative genomic hybridization and expression profiling.Gene regulation and systems biology · 2007Article
- A Krüppel-associated box-zinc finger protein, NT2, represses cell-type-specific promoter activity of the alpha 2(XI) collagen gene.Molecular and cellular biology · 2002Article
- A ligand-reversible dimerization system for controlling protein-protein interactions.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Activation of the c-fos enhancer by the erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites.Oncogene · 2000Article
- The zinc finger-associated SCAN box is a conserved oligomerization domain.Molecular and cellular biology · 1999Article
- A general strategy to enhance the potency of chimeric transcriptional activators.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Persistent increased DNA-binding and expression of serum response factor occur with epilepsy-associated long-term plasticity changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- The presence of transcription factors in chicken albumin, yolk and blastoderm.In vitro cellular & developmental biology. Animal · 1999Article
- The presence of transcription factors in fetal bovine sera.In vitro cellular & developmental biology. Animal · 1998Article
- A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I.Genes & development · 1997Article
- A versatile synthetic dimerizer for the regulation of protein-protein interactions.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation.Molecular and cellular biology · 1997Article
- ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter.Molecular and cellular biology · 1996Article
- YY1 facilitates the association of serum response factor with the c-fos serum response element.Molecular and cellular biology · 1995Article
- Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes.Human genetics · 1995Article
- Repression of transcriptional activity at a distance by the evolutionarily conserved KRAB domain present in a subfamily of zinc finger proteins.Nucleic acids research · 1994Article
- Developmental stage-specific regulation of atrial natriuretic factor gene transcription in cardiac cells.Molecular and cellular biology · 1994Article
- A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.Molecular and cellular biology · 1993Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Induction of c-fos transcription by serum growth factors requires the serum response element (SRE). The SRE is a multifunctional element which responds to several positively and negatively acting signals. To identify cellular proteins that might mediate functions of the SRE, we screened a human cDNA expression library with an SRE probe. We report the isolation and characterization of SRE-ZBP, a previously unidentified SRE-binding protein. SRE-ZBP is a member of the C2H2 zinc finger family of proteins exemplified by TFIIIA and the Drosophila Krüppel protein. The seven tandemly repeated zinc finger motifs in SRE-ZBP are sufficient for high-affinity binding to the SRE. We show that SRE-ZBP is a nuclear protein and identify a candidate cellular protein encoded by the SRE-ZBP gene. Because we cannot detect any DNA-binding activity attributable to the endogenous protein, we propose that SRE-ZBP activity may be subject to posttranslational regulation. Like c-fos mRNA, SRE-ZBP mRNA is serum inducible in HeLa cells, but with slower kinetics. The role of SRE-ZBP in the regulation of c-fos transcription remains unestablished, but this protein binds to a region of the SRE where mutations lead to derepression.
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