ArticleHypertension (Dallas, Tex. : 1979)2005
Role of the B1 kinin receptor in the regulation of cardiac function and remodeling after myocardial infarction.
Article in Hypertension (Dallas, Tex. : 1979), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- The antihypertensive effect of MK on spontaneously hypertensive rats through the AMPK/Akt/eNOS/NO and ERK1/2/Cx43 signaling pathways.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Kinins and Kinin Receptors in Cardiovascular and Renal Diseases.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Downregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling.Cellular signalling · 2015Article
- Exacerbation of DSS-induced colitis in mice lacking kinin B(1) receptors through compensatory up-regulation of kinin B(2) receptors: the role of tight junctions and intestinal homeostasis.British journal of pharmacology · 2013Article
- Protective role of AT(2) and B(1) receptors in kinin B(2)-receptor-knockout mice with myocardial infarction.Clinical science (London, England : 1979) · 2013Article
- The kallikrein-kinin system and oxidative stress.Current opinion in nephrology and hypertension · 2012Review
- Local angiotensin II aggravates cardiac remodeling in hypertension.American journal of physiology. Heart and circulatory physiology · 2010Article
- Article
- Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.Endocrinology · 2010Article
- Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function.Hypertension (Dallas, Tex. : 1979) · 2010Review
- Article
- The kinin B1 receptor contributes to the cardioprotective effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in mice.Experimental physiology · 2009Article
- Tissue kallikrein elicits cardioprotection by direct kinin b2 receptor activation independent of kinin formation.Hypertension (Dallas, Tex. : 1979) · 2008Article
- Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2 receptors gene knockout mice.Circulation · 2008Article
- Bradykinin [corrected] B1 receptor antagonism is beneficial in renal ischemia-reperfusion injury.PloS one · 2008Article
- Tissue kallikrein and kinin infusion rescues failing myocardium after myocardial infarction.Journal of cardiac failure · 2007Article
- Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling.Peptides · 2007Article
- Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension.Vascular pharmacology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Kinins exert cardioprotective effects via 2 G-protein-coupled receptors, B1 and B2. Using B1 kinin receptor gene knockout mice (B1-/-), we tested the hypotheses that the B1 receptor plays an important role in preservation of cardiac function, whereas lack of B1 may accelerate cardiac remodeling and dysfunction after myocardial infarction, and that B2 receptors may compensate for lack of B1, whereas blockade of B2 receptors in B1-/- mice may cause further deterioration of cardiac function and remodeling. Female B1-/- mice and wild-type controls (C57BL/6J, B1+/+) underwent sham surgery or myocardial infarction and were treated with either vehicle or B2-antagonist (icatibant, 500 microg/kg per day, subcutaneous) for 8 weeks. We found that in sham myocardial infarction, B1-/- mice had a larger left ventricular diastolic chamber dimension both initially and at 4 to 8 weeks compared with B1+/+. Left ventricular mass and myocyte size were also larger in B1-/- with sham operation than in B1+/+, although cardiac function did not differ between strains. After myocardial infarction, cardiac remodeling and function were similar in both strains, although B1-/- mice tended to have lower blood pressure. Blockade of B2 receptors tended to worsen cardiac remodeling and dysfunction in B1-/- but not in B1+/+. These results may suggest that B2 receptors play an important role in compensating for lack of B1 receptors in mice with myocardial infarction. Dual blockade of both B1 and B2 eliminates this compensation, leading to further deterioration of cardiac dysfunction and remodeling after myocardial infarction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.