ArticleThe Journal of cell biology2005
Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
154 citing papers in PubMed, 1 synthesis or guideline pooled it, 288 citations in OpenAlex.
- Diagnostic and Prognostic Utility of Non-Invasive Multimodal Imaging in Chronic Wound Monitoring: a Systematic Review.Journal of medical systems · 2017Pooled it
- Article
- TTNCell reports · 2026Article
- Drosophila Abi maintains blood cell homeostasis by promoting clathrin-mediated endocytosis of Notch.The Journal of cell biology · 2026Article
- Drosophila complement-like Mcr acts as a wound-induced inflammatory chemoattractant.Current biology : CB · 2025Article
- Abrupt-mediated control of ninjurins regulates Drosophila sessile haemocyte compartments.Development (Cambridge, England) · 2024Article
- Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation.PLoS genetics · 2024Article
- Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila.Nature cell biology · 2024Article
- Rho-associated kinase regulates Langerhans cell morphology and responsiveness to tissue damage.Cell reports · 2024Article
- Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation.bioRxiv : the preprint server for biology · 2023Article
- The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues iniScience · 2023Article
- Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo.Immunological reviews · 2023Review
- Regeneration in calcareous sponge relies on 'purse-string' mechanism and the rearrangements of actin cytoskeleton.Cell and tissue research · 2023Article
- Coordinated efforts of different actin filament populations are needed for optimal cell wound repair.Molecular biology of the cell · 2023Article
- Macrophage subpopulation identity inFrontiers in immunology · 2023Article
- Gcm counteracts Toll-induced inflammation and impacts hemocyte number through cholinergic signaling.Frontiers in immunology · 2023Article
- Role of Macrophages in Wound Healing.Cold Spring Harbor perspectives in biology · 2022Review
- Wound Healing Insights from Flies and Fish.Cold Spring Harbor perspectives in biology · 2022Review
- Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo.Development (Cambridge, England) · 2022Article
- Injury-induced inflammatory signaling and hematopoiesis inProceedings of the National Academy of Sciences of the United States of America · 2022Article
94 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Aa robust inflammatory response to tissue damage and infection is conserved across almost all animal phyla. Neutrophils and macrophages, or their equivalents, are drawn to the wound site where they engulf cell and matrix debris and release signals that direct components of the repair process. This orchestrated cell migration is clinically important, and yet, to date, leukocyte chemotaxis has largely been studied in vitro. Here, we describe a genetically tractable in vivo wound model of inflammation in the Drosophila melanogaster embryo that is amenable to cinemicroscopy. For the first time, we are able to examine the roles of Rho-family small GTPases during inflammation in vivo and show that Rac-mediated lamellae are essential for hemocyte motility and Rho signaling is necessary for cells to retract from sites of matrix- and cell-cell contacts. Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.