ArticleThe Journal of experimental medicine2005
Regulation of T helper type 2 cell differentiation by murine Schnurri-2.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Refined phenotyping of vaccine responses reveals transcriptomic determinants of neutralizing antibody heterogeneity.NPJ vaccines · 2026Article
- Expanding the Phenotypic Spectrum ofMolecular syndromology · 2022Article
- Schnurri 3 promotes Th2 cytokine production during the late phase of T-cell antigen stimulation.European journal of immunology · 2022Article
- Identification of Somatic Mutation-Driven Immune Cells by Integrating Genomic and Transcriptome Data.Frontiers in cell and developmental biology · 2021Article
- Nuclear factor kappa B activation appears weaker in schizophrenia patients with high brain cytokines than in non-schizophrenic controls with high brain cytokines.Journal of neuroinflammation · 2020Article
- Mechanisms of Maintenance of Foot-and-Mouth Disease Virus Persistence Inferred From Genes Differentially Expressed in Nasopharyngeal Epithelia of Virus Carriers and Non-carriers.Frontiers in veterinary science · 2020Article
- Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability.Molecular brain · 2017Article
- Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Immature dentate gyrus: an endophenotype of neuropsychiatric disorders.Neural plasticity · 2013Review
- Genome-wide repression of NF-κB target genes by transcription factor MIBP1 and its modulation by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase.The Journal of biological chemistry · 2012Article
- Article
- A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy.Cancer science · 2010Article
- STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells.The Journal of experimental medicine · 2010Article
- Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation.The Journal of biological chemistry · 2008Article
- Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development.Gene expression · 2007Article
- Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Reciprocal regulation of nuclear factor kappa B and its inhibitor ZAS3 after peripheral nerve injury.BMC neuroscience · 2006Article
- CLIC4 and Schnurri-2: a dynamic duo in TGF-beta signaling with broader implications in cellular homeostasis and disease.Nucleus (Austin, Tex.)Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schnurri (Shn) is a large zinc finger protein implicated in cell growth, signal transduction, and lymphocyte development. Vertebrates possess at least three Shn orthologues (Shn-1, Shn-2, and Shn-3), which appear to act within the bone morphogenetic protein, transforming growth factor beta, and activin signaling pathways. However, the physiological functions of the Shn proteins remain largely unknown. In Shn-2-deficient mice, mature peripheral T cells exhibited normal anti-T cell receptor-induced proliferation, although there was dramatic enhancement in the differentiation into T helper type (Th)2 cells and a marginal effect on Th1 cell differentiation. Shn-2-deficient developing Th2 cells showed constitutive activation of nuclear factor kappaB (NF-kappaB) and enhanced GATA3 induction. Shn-2 was able to compete with p50 NF-kappaB for binding to a consensus NF-kappaB motif and inhibit NF-kappaB-driven promoter activity. Thus, Shn-2 plays a crucial role in the control of Th2 cell differentiation by regulating NF-kappaB function.
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