ReviewWorld journal of surgery2005
Roles of neuropilins in neuronal development, angiogenesis, and cancers.
Review in World journal of surgery, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Regulated cell death in cancer: Mechanisms, crosstalk, and opportunities for therapy.Cancer letters · 2025Review
- MiR-148a deletion protects from bone loss in physiological and estrogen-deficient mice by targeting NRP1.Cell death discovery · 2022Article
- MicroRNAs and Synaptic Plasticity: From Their Molecular Roles to Response to Therapy.Molecular neurobiology · 2022Review
- Article
- Common Expression Quantitative Trait Loci Shared by Histone Genes.International journal of genomics · 2017Article
- Replenishment of microRNA-188-5p restores the synaptic and cognitive deficits in 5XFAD Mouse Model of Alzheimer's Disease.Scientific reports · 2016Article
- NRP1 is targeted by miR-130a and miR-130b, and is associated with multidrug resistance in epithelial ovarian cancer based on integrated gene network analysis.Molecular medicine reports · 2016Article
- Metastasis: Other Side of the Coin.Frontiers in oncology · 2015Review
- Role of the nervous system in cancer metastasis.Oncology letters · 2013Article
- Lymphatic and angiogenic candidate genes predict the development of secondary lymphedema following breast cancer surgery.PloS one · 2013Article
- Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth.The Journal of experimental medicine · 2012Article
- An activity-regulated microRNA, miR-188, controls dendritic plasticity and synaptic transmission by downregulating neuropilin-2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neuropilin-2: a novel biomarker for malignant melanoma?Human pathology · 2012Article
- Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland.Development (Cambridge, England) · 2011Article
- Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction.Cancer research · 2011Article
- Differential expression of neuronal genes in Müller glia in two- and three-dimensional cultures.Investigative ophthalmology & visual science · 2011Article
- Screening genes related to development and injury of the mouse optic nerve by cDNA microarrays.Cellular and molecular neurobiology · 2010Article
- Suppression subtractive hybridization profiles of radial growth phase and metastatic melanoma cell lines reveal novel potential targets.BMC cancer · 2008Article
- Semaphorin signals on the road to cancer invasion and metastasis.Cell adhesion & migrationReview
- Pro-angiogenic effects of Guo Min decoction in a zebrafish model.Tzu chi medical journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Neuropilin-1 (NRP1) and neuropilin-2 (NRP2) are transmembrane glycoproteins that have been characterized as receptors for both semaphorins for neuronal guidance and vascular endothelial growth factor (VEGF) for angiogenesis. Biologic properties of NRPs have been linked to their unique domain structures. However, molecular interaction among NRPs, VEGF, and VEGF receptors is still not clear. Although several types of cancer cells can express NRPs, the role of NRPs in tumor pathogenesis is largely unknown. Thus, future investigations should include determining the effects and mechanisms of NRPs on proliferation, apoptosis, and migration of neuronal , endothelial, and cancer cells. Study of protein-protein interaction, signal transduction pathways, and NRP-mediated gene expression is particularly important to understand NRPs functions, which may have significant clinical applications in the treatment of neurological disorders, cardiovascular diseases, and certain cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.