ArticleJournal of molecular evolution2005
Molecular evolution of ldpA, a gene mediating the circadian input signal in cyanobacteria.
Article in Journal of molecular evolution, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Minimal tool set for a prokaryotic circadian clock.BMC evolutionary biology · 2017Article
- Patterns of nucleotide diversity of the ldpA circadian gene in closely related species of cyanobacteria from extreme cold deserts.Applied and environmental microbiology · 2013Article
- Extreme conservation and non-neutral evolution of the cpmA Circadian locus in a globally distributed Chroococcidiopsis sp. from naturally stressful habitats.Molecular biology and evolution · 2012Article
- Circadian input kinases and their homologs in cyanobacteria: evolutionary constraints versus architectural diversification.Journal of molecular evolution · 2010Article
- Proteins found in a CikA interaction assay link the circadian clock, metabolism, and cell division in Synechococcus elongatus.Journal of bacteriology · 2008Article
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Authors and funding
1 author.
Funding
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Abstract
The ldpA gene is an element of the cyanobacterial circadian system and mediates input to the clock. Using complete prokaryotic genomes from various public databases, I analyzed the structure and phylogeny of the ldpA genes. This gene belongs to the large superfamily of ferredoxins and has a HycB domain as a core element of its structure. In addition to this domain, ldpA has two conserved terminal domains that are specific to this gene and have no homologs in the databases. All three domains are under different selective constraints. The ldpA tree topology features two very distinct clades that are essentially the same as those in the previously reported trees of the sasA gene and the kaiBC operon, two other elements of the circadian system. The data on the ldpA polymorphism and evolutionary patterns give further support to the existence of two types of the system, kaiABC- and kaiBC-based, respectively. Each type has specific functional and selective constraints, which have likely been attained through highly concordant evolution of the system's components.
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