Retinoic acid and arsenic for treating acute promyelocytic leukemia.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

20 citing papers in PubMed.

1. Differentiation therapy in acute myeloid leukaemia: molecular basis, clinical progress, and future perspectives.Frontiers in medicine · 2026
   Review
2. Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation.Cell reports · 2025
   Article
3. Arsenic trioxide-induced apoptosis contributes to suppression of viral reservoir in SIV-infected rhesus macaques.Microbiology spectrum · 2023
   Article
4. Pharmaceutical/Clinical Strategies in the Treatment of Acute Promyelocytic Leukemia: All-Trans Retinoic Acid Encapsulation by Spray-Drying Technology as an Innovative Approach-Comprehensive Overview.Pharmaceuticals (Basel, Switzerland) · 2023
   Review
5. Application of High Throughput Technologies in the Development of Acute Myeloid Leukemia Therapy: Challenges and Progress.International journal of molecular sciences · 2022
   Review
6. Parthenolide and arsenic trioxide co-trigger autophagy-accompanied apoptosis in hepatocellular carcinoma cells.Frontiers in oncology · 2022
   Article
7. Current views on the genetic landscape and management of variant acute promyelocytic leukemia.Biomarker research · 2021
   Review
8. Autophagy: New Insights into Mechanisms of Action and Resistance of Treatment in Acute Promyelocytic leukemia.International journal of molecular sciences · 2019
   Review
9. Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia.Journal of hematology & oncology · 2019
   Article
10. Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-Haematologica · 2019
    Article
11. How to manage acute promyelocytic leukemia.Leukemia · 2012
    Review
12. From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia.Blood · 2011
    Review
13. An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis.Environmental health perspectives · 2011
    Review
14. Arsenic exposure and the induction of human cancers.Journal of toxicology · 2011
    Article
15. The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel.BMC medical genomics · 2010
    Article
16. Decomposition of gene expression state space trajectories.PLoS computational biology · 2009
    Article
17. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2008
    Article
18. The presence of a single PML-RARA isoform lacking exon 5 in FISH-negative APL samples.Leukemia · 2008
    Article
19. Treatment of acute promyelocytic leukaemia with all-trans retinoic acid and arsenic trioxide: a paradigm of synergistic molecular targeting therapy.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2007
    Review
20. Biological screening of natural products and drug innovation in China.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2007
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

5 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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