ArticleJournal of clinical microbiology2005
Evidence of Borrelia autoimmunity-induced component of Lyme carditis and arthritis.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 79 citations in OpenAlex.
- Long-term Cardiac Sequelae in Lyme Carditis: A Review.Current cardiology reviews · 2026Review
- Characterizing the impact of intracutaneous dissemination on host responses duringFrontiers in immunology · 2026Article
- Aspects of the Immunopathogenesis of Lyme Arthritis.Microorganisms · 2025Review
- Lyme Carditis With Complete Heart Block.Cureus · 2025Article
- Cardiac Magnetic Resonance Imaging in Lyme Carditis-A Case Series and Review of Literature.Journal of cardiovascular development and disease · 2024Review
- Evidence for the Presence ofMicroorganisms · 2024Article
- Antigenicity and immunogenicity of different morphological forms of Borrelia burgdorferi sensu lato spirochetes.Scientific reports · 2024Article
- Lyme Carditis: An Infectious Cause of Atrioventricular Block - A Case Report.Arquivos brasileiros de cardiologia · 2024Article
- Lyme disease and the pursuit of a clinical cure.Frontiers in medicine · 2023Review
- Neuropsychiatric Symptoms and Tick-Borne Diseases.Current topics in behavioral neurosciences · 2023Article
- Lyme Carditis: From Pathophysiology to Clinical Management.Pathogens (Basel, Switzerland) · 2022Review
- Fulminant Lyme myocarditis without any other signs of Lyme disease in a 37-year-old male patient with microscopic polyangiitis-a case report.European heart journal. Case reports · 2022Article
- Anti-lysoganglioside and other anti-neuronal autoantibodies in post-treatment Lyme Disease and Erythema Migrans after repeat infection.Brain, behavior, & immunity - health · 2020Article
- Lyme Endocarditis as an Emerging Infectious Disease: A Review of the Literature.Frontiers in microbiology · 2020Review
- Bacterial Amyloids: The Link between Bacterial Infections and Autoimmunity.Trends in microbiology · 2019Review
- Lyme carditis presenting as atrial fibrillation.BMJ case reports · 2019Article
- ACVIM consensus update on Lyme borreliosis in dogs and cats.Journal of veterinary internal medicine · 2018Article
- The Contribution of Autoantibodies to Inflammatory Cardiovascular Pathology.Frontiers in immunology · 2018Review
- Lyme Carditis: An Interesting Trip to Third-Degree Heart Block and Back.Case reports in cardiology · 2016Article
- Lyme carditis--diagnosis, treatment and prognosis.Deutsches Arzteblatt international · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
We investigated the possibility that manifestations of Lyme disease in certain hosts, such as arthritis and carditis, may be autoimmunity mediated due to molecular mimicry between the bacterium Borrelia burgdorferi and self-components. We first compared amino acid sequences of Streptococcus pyogenes M protein, a known inducer of antibodies that are cross-reactive with myosin, and B. burgdorferi and found significant homologies with OspA protein. We found that S. pyogenes M5-specific antibodies and sera from B. burgdorferi-infected mice reacted with both myosin and B. burgdorferi proteins by Western blots and enzyme-linked immunosorbent assay. To investigate the relationship between self-reactivity and the response to B. burgdorferi, NZB mice, models of autoimmunity, were infected. NZB mice infected with B. burgdorferi developed higher degrees of joint swelling and higher anti-B. burgdorferi immunoglobulin M cross-reactive responses than other strains with identical major histocompatibility complex (DBA/2 and BALB/c). These studies reveal immunological cross-reactivity and suggest that B. burgdorferi may share common epitopes which mimic self-proteins. These implications could be important for certain autoimmunity-susceptible individuals or animals who become infected with B. burgdorferi.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.