ArticleJournal of clinical microbiology2005
Molecular analysis of microbial diversity in advanced caries.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 253 citations in OpenAlex.
- Clinical efficacy and the antimicrobial potential of silver formulations in arresting dental caries: a systematic review.BMC oral health · 2020Pooled it
- Can the Acid-formation Potential of Saliva Detect a Caries-related Shift in the Oral Microbiome?Oral health & preventive dentistry · 2022Trial
- The dental plaque microbiome in health and disease.PloS one · 2013Trial
- Direct and transdentinal antibacterial activity of synthetic and biomimetic agents against different Streptococcus and Lactobacillus strains.European oral research · 2026Article
- Construction of an early childhood caries risk prediction model based on the oral microbiome: a nested case‒control study.BMC oral health · 2025Article
- Inter-kingdom interactions and environmental influences on the oral microbiome in severe early childhood caries.Microbiology spectrum · 2025Article
- Effects of clear aligners and traditional removable appliances on oral microbiome in mixed dentition: a comparative study.BMC oral health · 2024Article
- Periodontal inflammatory and microbial profiles in healthy young African Americans and Caucasians.Journal of clinical periodontology · 2024Article
- Prevalence of salivary microbial load and lactic acid presence in diabetic and non-diabetic individuals with different dental caries stages.Restorative dentistry & endodontics · 2024Article
- The Evolving Microbiome of Dental Caries.Microorganisms · 2024Review
- Salivary levels of five microorganisms of root caries in nursing home elderly: a preliminary investigation.BMC oral health · 2023Article
- A comprehensive review of the application of probiotics and postbiotics in oral health.Frontiers in cellular and infection microbiology · 2023Review
- Dental caries and their microbiomes in children: what do we do now?Journal of oral microbiology · 2023Review
- Caries Management-The Role of Surface Interactions in De- and Remineralization-Processes.Journal of clinical medicine · 2022Review
- Effect of Bacteriocin-Like Inhibitory Substance (BLIS) fromFood science of animal resources · 2022Article
- Overexpression of proinflammatory cytokines in dental pulp tissue and distinct bacterial microbiota in carious teeth of Mexican Individuals.Frontiers in cellular and infection microbiology · 2022Article
- From Mouth to Brain: Distinct Supragingival Plaque Microbiota Composition in Cerebral Palsy Children With Caries.Frontiers in cellular and infection microbiology · 2022Article
- Bacterial levels and amount of endotoxins in carious dentin within reversible pulpitis scenarios.Clinical oral investigations · 2021Article
- Dysbiosis of Oral Microbiota During Oral Squamous Cell Carcinoma Development.Frontiers in oncology · 2021Article
- Physiopathology of nitric oxide in the oral environment and its biotechnological potential for new oral treatments: a literature review.Clinical oral investigations · 2020Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Real-time PCR analysis of the total bacterial load in advanced carious lesions has shown that the total load exceeds the number of cultivable bacteria. This suggests that an unresolved complexity exists in bacteria associated with advanced caries. In this report, the profile of the microflora of carious dentine was explored by using DNA extracted from 10 lesions selected on the basis of comparable total microbial load and on the relative abundance of Prevotella spp. Using universal primers for the 16S rRNA gene, PCR amplicons were cloned, and approximately 100 transformants were processed for each lesion. Phylogenetic analysis of 942 edited sequences demonstrated the presence of 75 species or phylotypes in the 10 carious lesions. Up to 31 taxa were represented in each sample. A diverse array of lactobacilli were found to comprise 50% of the species, with prevotellae also abundant, comprising 15% of the species. Other taxa present in a number of lesions or occurring with high abundance included Selenomonas spp., Dialister spp., Fusobacterium nucleatum, Eubacterium spp., members of the Lachnospiraceae family, Olsenella spp., Bifidobacterium spp., Propionibacterium sp., and Pseudoramibacter alactolyticus. The mechanisms by which such diverse patterns of bacteria extend carious lesions, including the aspect of infection of the vital dental pulp, remain unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.