ArticleJournal of clinical microbiology2005
Genetic variants of Anaplasma phagocytophilum infecting dogs in Western Washington State.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 90 citations in OpenAlex.
- Two Autochthonous Cases of Anaplasmosis, Washington, USA, 2022-2023.Emerging infectious diseases · 2025Article
- Review of Molecular Tools Used in Diagnosis ofAnimals : an open access journal from MDPI · 2025Review
- Assessment of the speed of transmission of Ehrlichia canis, Anaplasma phagocytophilum, and Borrelia burgdorferi sensu stricto by infected ticks through an in vitro experimental model.Parasites & vectors · 2025Article
- Parasites and lameness in domestic animals.Veterinary research communications · 2025Review
- Detection of Anaplasma spp. and Ehrlichia spp. in dogs from a veterinary teaching hospital in Italy: a retrospective study 2012-2020.Veterinary research communications · 2024Article
- Molecular and Serological Detection ofAnimals : an open access journal from MDPI · 2023Article
- Molecular Characterization ofAnimals : an open access journal from MDPI · 2022Article
- Exposure to Tick-Borne Pathogens in Cats and Dogs Infested WithFrontiers in veterinary science · 2021Article
- Epidemiological and Clinicopathological Features ofFrontiers in veterinary science · 2021Review
- Rickettsia and Anaplasma species in Dermacentor andersoni ticks from Washington.Ticks and tick-borne diseases · 2020Article
- Molecular Detection ofPathogens (Basel, Switzerland) · 2020Article
- Ecology and Epidemiology of Tickborne Pathogens, Washington, USA, 2011-2016.Emerging infectious diseases · 2020Article
- Molecular prevalence ofOpen veterinary journal · 2019Article
- A review on the occurrence of companion vector-borne diseases in pet animals in Latin America.Parasites & vectors · 2019Review
- Transmission of Anaplasma phagocytophilum (Foggie, 1949) by Ixodes ricinus (Linnaeus, 1758) ticks feeding on dogs and artificial membranes.Parasites & vectors · 2019Article
- Granulocytic anaplasmosis in 2 dogs from Quebec.The Canadian veterinary journal = La revue veterinaire canadienne · 2018Article
- A lifelong study of a pack Rhodesian ridgeback dogs reveals subclinical and clinical tick-borne Anaplasma phagocytophilum infections with possible reinfection or persistence.Parasites & vectors · 2018Article
- A Bayesian spatio-temporal model for forecasting Anaplasma species seroprevalence in domestic dogs within the contiguous United States.PloS one · 2017Article
- Molecular detection and characterization of Anaplasma spp. in sheep and cattle from Xinjiang, northwest China.Parasites & vectors · 2015Article
- Analysis of the population structure of Anaplasma phagocytophilum using multilocus sequence typing.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eight dogs from western Washington State suspected of being infected with Anaplasma phagocytophilum because of the finding of morulae in peripheral blood neutrophils were studied for determination of the etiologic agent of disease. All cases were diagnosed between April 2003 and April 2004. Six of the eight dogs had no travel history during the 6 months prior to presentation. Two dogs had traveled within the Northwest United States and Canada. Fever, lethargy, and anorexia were the most common clinical signs in the dogs. Lymphopenia, thrombocytopenia, and an elevated activity of alkaline phosphatase in the serum were the most common laboratory findings. All dogs tested during the acute phase of clinical signs were seropositive for A. phagocytophilum antibodies but negative for Ehrlichia canis antibodies. PCR amplification and direct sequencing of portions of the 16S rRNA gene from the whole blood of all seven dogs that were tested yielded A. phagocytophilum after a comparison to bacterial sequences available in the GenBank database. Five genetic variants were identified based on one or two nucleotide differences in the 16S rRNA gene sequences at nucleotide positions 54, 84, 86, and 120. Individual dogs were infected with more than one variant. Treatment with doxycycline or tetracycline resulted in a rapid resolution of clinical signs. The occurrence of canine granulocytic anaplasmosis in western Washington State suggests that A. phagocytophilum infection should be considered in differential diagnoses of dogs presenting with lethargy, anorexia, fever, and lameness, particularly in the context of lymphopenia, thrombocytopenia, and increased serum alkaline phosphatase. The zoonotic importance of A. phagocytophilum should support an increase in surveillance for horses and people residing in this area.
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