ArticleBiophysical journal2005
Protons may leak through pure lipid bilayers via a concerted mechanism.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- Practical Tips for the Application of HDX-MS to Membrane Proteins, Biomolecular Condensates, and Weak Protein Binders.Journal of the American Society for Mass Spectrometry · 2025Article
- Local pH at Nonionic and Zwitterionic Lipid/Water Interfaces Revealed by Heterodyne-Detected Electronic Sum-Frequency Generation: A Unified View to Predict Interfacial pH of Biomembranes.The journal of physical chemistry. B · 2023Article
- The Underlying Mechanism of Modulation of Transient Receptor Potential Melastatin 3 by protons.Frontiers in pharmacology · 2021Article
- Defect-Assisted Permeation Through a Phospholipid Membrane: Experimental and Computational Study of the Peptide WKW.The journal of physical chemistry. B · 2019Article
- An update of the chemiosmotic theory as suggested by possible proton currents inside the coupling membrane.Open biology · 2019Review
- Ion Permeation through a Phospholipid Membrane: Transition State, Path Splitting, and Calculation of Permeability.Journal of chemical theory and computation · 2019Article
- Ladderane phospholipids form a densely packed membrane with normal hydrazine and anomalously low proton/hydroxide permeability.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Proton Gradients as a Key Physical Factor in the Evolution of the Forced Transport Mechanism Across the Lipid Membrane.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2016Article
- Computationally Efficient Multiconfigurational Reactive Molecular Dynamics.Journal of chemical theory and computation · 2012Article
- Insights into the mechanism of proton transport in cytochrome c oxidase.Journal of the American Chemical Society · 2012Article
- A view of hydrogen/hydroxide flux across lipid membranes.The Journal of membrane biology · 2010Article
- Free energy for the permeation of Na(+) and Cl(-) ions and their ion-pair through a zwitterionic dimyristoyl phosphatidylcholine lipid bilayer by umbrella integration with harmonic fourier beads.Journal of the American Chemical Society · 2009Article
- Simulations of skin barrier function: free energies of hydrophobic and hydrophilic transmembrane pores in ceramide bilayers.Biophysical journal · 2008Article
- Protein exchange dynamics at chemoreceptor clusters in Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Ion transport across transmembrane pores.Biophysical journal · 2007Article
- Proton solvation and transport in aqueous and biomolecular systems: insights from computer simulations.The journal of physical chemistry. B · 2007Review
- Charge delocalization in proton channels, I: the aquaporin channels and proton blockage.Biophysical journal · 2007Article
- Mechanisms of passive ion permeation through lipid bilayers: insights from simulations.The journal of physical chemistry. B · 2006Article
- Lipid raft components cholesterol and sphingomyelin increase H+/OH- permeability of phosphatidylcholine membranes.The Biochemical journal · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Protons are known to permeate pure lipid bilayers at a rate that is anomalous compared to those of other small monovalent cations. The prevailing mechanism via which they cross the membrane is still unclear, and it is unknown how to probe the mechanism directly by experiment. One of the more popular theories assumes the formation of membrane-spanning single-file water wires providing a matrix along which the protons can "hop" over the barrier. However, free energy calculations on such structures (without the presence of an excess proton) suggest that this mechanism alone cannot account for the observed permeation rates. We use the multistate empirical valence bond method to directly study water structures surrounding a (delocalized) excess proton on its way through the membrane. We find that membrane-spanning networks, rather than single-file chains, are formed around the proton. We also find that such structures are considerably stabilized in the presence of the proton, with lifetimes of several hundreds of picoseconds. The observed structures are suggestive of a new, concerted, mechanism and provide some direction for further investigation.
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