ArticleGenetics2005
RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Genome-Wide Expression Profiling and Phenotypic Analysis of Downstream Targets Identify the Fox Transcription Factor Jumeau as a Master Regulator of Cardiac Progenitor Cell Division.International journal of molecular sciences · 2024Article
- Cross-Talk between Wnt Signaling and Src Tyrosine Kinase.Biomedicines · 2022Review
- Article
- Identifying Genetic Players in Cell Sheet Morphogenesis Using aG3 (Bethesda, Md.) · 2018Article
- SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis ofDevelopment (Cambridge, England) · 2017Article
- Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway.Development (Cambridge, England) · 2013Article
- Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy.Arthritis research & therapy · 2013Review
- Transcriptome Profiling Following Neuronal and Glial Expression of ALS-Linked SOD1 in Drosophila.G3 (Bethesda, Md.) · 2013Article
- Accurate measurements of dynamics and reproducibility in small genetic networks.Molecular systems biology · 2013Article
- Genome-wide polycomb target gene prediction in Drosophila melanogaster.Nucleic acids research · 2012Article
- crinkled reveals a new role for Wingless signaling in Drosophila denticle formation.Development (Cambridge, England) · 2012Article
- Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation.Journal of cell science · 2010Article
- Wnt signaling from development to disease: insights from model systems.Cold Spring Harbor perspectives in biology · 2009Review
- RacGAP50C directs perinuclear gamma-tubulin localization to organize the uniform microtubule array required for Drosophila myotube extension.Development (Cambridge, England) · 2009Article
- Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.Cell · 2008Article
- Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.Molecular and cellular biology · 2007Article
- Flying at the head of the pack: Wnt biology in Drosophila.Oncogene · 2006Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Wingless (Wg)/Wnt signal transduction pathway directs a variety of cell fate decisions in developing animal embryos. Despite the identification of many Wg pathway components to date, it is still not clear how these elements work together to generate cellular identities. In the ventral epidermis of Drosophila embryos, Wg specifies cells to secrete a characteristic pattern of denticles and naked cuticle that decorate the larval cuticle at the end of embryonic development. We have used the Drosophila ventral epidermis as our assay system in a series of genetic screens to identify new components involved in Wg signaling. Two mutant lines that modify wg-mediated epidermal patterning represent the first loss-of-function mutations in the RacGap50C gene. These mutations on their own cause increased stabilization of Armadillo and cuticle pattern disruptions that include replacement of ventral denticles with naked cuticle, which suggests that the mutant embryos suffer from ectopic Wg pathway activation. In addition, RacGap50C mutations interact genetically with naked cuticle and Axin, known negative regulators of the Wg pathway. These phenotypes suggest that the RacGap50C gene product participates in the negative regulation of Wg pathway activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.