ArticleProceedings of the National Academy of Sciences of the United States of America2005
Abnormal GABAA receptors from the human epileptic hippocampal subiculum microtransplanted to Xenopus oocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Multi-omics and electrophysiological examination of GABAMolecular psychiatry · 2026Article
- Review
- Molecular Mechanisms of Epilepsy: The Role of the Chloride Transporter KCC2.Journal of molecular neuroscience : MN · 2022Review
- Mammalian Brain CaMembranes · 2022Article
- Synaptic Reshaping and Neuronal Outcomes in the Temporal Lobe Epilepsy.International journal of molecular sciences · 2021Review
- GABAFrontiers in neuroscience · 2021Article
- Phytocannabinoids in Neurological Diseases: Could They Restore a Physiological GABAergic Transmission?International journal of molecular sciences · 2020Review
- Using Xenopus oocytes in neurological disease drug discovery.Expert opinion on drug discovery · 2020Review
- Neurosteroid regulation of GABABrain research · 2019Review
- Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function.Frontiers in neurology · 2019Review
- Does epilepsy cause a reversion to immature function?Advances in experimental medicine and biology · 2014Review
- Changes in the sensitivity of GABAA current rundown to drug treatments in a model of temporal lobe epilepsy.Frontiers in cellular neuroscience · 2013Article
- Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue.Nature communications · 2012Article
- Functional rundown of gamma-aminobutyric acid(A) receptors in human hypothalamic hamartomas.Annals of neurology · 2011Article
- Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex.Neuroscience letters · 2010Article
- Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Properties of glutamate receptors of Alzheimer's disease brain transplanted to frog oocytes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- GABAergic synaptic inhibition is reduced before seizure onset in a genetic model of cortical malformation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
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7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the properties of GABAA receptors microtransplanted from the human temporal lobe epilepsy (TLE)-associated brain regions to Xenopus oocytes. Cell membranes, isolated from surgically resected brain specimens of drug-resistant TLE patients, were injected into frog oocytes, which rapidly incorporated human GABAA receptors, and any associated proteins, into their surface membrane. The receptors originating from different epileptic brain regions had a similar run-down but an affinity for GABA that was approximately 60% lower for the subiculum receptors than for receptors issuing from the hippocampus proper or the temporal lobe neocortex. Moreover, GABA currents recorded in oocytes injected with membranes from the subiculum had a more depolarized reversal potential compared with the hippocampus proper or neocortex of the same patients. Quantitative RT-PCR analysis was performed of the GABAA receptor alpha1- to alpha5-, beta1- to beta3-, gamma2- to gamma3-, and delta-subunit mRNAs. The levels of expression of the alpha3-, alpha5-, and beta1- to beta3- subunit mRNAs are significantly higher, with the exception of gamma2-subunit whose expression is lower, in subiculum compared with neocortex specimens. Our results suggest that an abnormal GABA-receptor subunit transcription in the TLE subiculum leads to the expression of GABAA receptors with a relatively low affinity. This abnormal behavior of the subiculum GABAA receptors may contribute to epileptogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.