ArticleThe Journal of experimental medicine1992
Differential induction of transcription factors that regulate the interleukin 2 gene during anergy induction and restimulation.
Article in The Journal of experimental medicine, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice.The Journal of clinical investigation · 2009Article
- Biochemical features of anergic T cells.Immunologic research · 1998Review
- Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients.Transplantation · 1996Article
- Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions.Microbiological reviews · 1996Review
- In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes.Transplantation · 1995Article
- Staphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein-tyrosine kinase 3 (Jak3) and signal transducers and activators of transcription (Stat proteins).Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Negative transcriptional regulation in anergic T cells.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells.The Journal of experimental medicine · 1995Article
- CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy.The Journal of experimental medicine · 1994Article
- AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.The EMBO journal · 1994Article
- Inhibition of activation of transcription factor AP-1 by CD28 signalling in human T-cells.The Biochemical journal · 1994Article
- Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles.The Journal of experimental medicine · 1994Article
- Expression and functional significance of an additional ligand for CTLA-4.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Costimulator deficient antigen presentation by an endothelial cell line induces a nonproliferative T cell activation response without anergy.The Journal of experimental medicine · 1993Article
- Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Article
- Molecular regulation of human interleukin 2 and T-cell function by interleukin 4.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.Molecular and cellular biology · 1993Article
- T-cell lymphokine response to orally administered proteins during priming and unresponsiveness.Immunology · 1993Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
T cell activation requires two distinct signals. The first is delivered through the antigen-specific T cell receptor (TCR), and the second is provided by costimulatory molecule(s) present on the surface of the antigen-presenting cell (APC). Stimulation of T helper type 1 T cell clones through the TCR in the absence of the costimulatory activity results in a lack of interleukin 2 (IL-2) secretion and proliferation, and the induction of a long-lived state of nonresponsiveness, termed anergy. In this study, we have examined the transcription factors involved in IL-2 gene expression that are expressed after stimulation of normal T cell clones through the TCR with and without engagement of the necessary costimulatory molecule(s). Antigen-specific activation of the clones results in the induction of a similar pattern of transcription factors that have been previously shown to regulate IL-2 expression. In contrast, antigen presentation by chemically fixed APC, a condition that results in T cell anergy, induces neither NF-AT nor one of the two NF-kappa B binding factors. Thus, the failure to express IL-2 during the induction of T cell anergy may be attributed to the absence of these two transcription factors. When anergized T cells are restimulated with antigen and conventional APC, they induce the transcription factors associated with IL-2 expression, but they fail to synthesize measurable IL-2. Taken together, these data indicate that the control of IL-2 gene expression during anergy induction and during normal stimulation of anergized cells are distinct, and suggest the presence of additional regulatory elements in the IL-2 gene.
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