ArticleJournal of molecular evolution2004
A new classification scheme of the genetic code.
Article in Journal of molecular evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Circular Tessera Codes in the Evolution of the Genetic Code.Bulletin of mathematical biology · 2020Article
- An integrated, structure- and energy-based view of the genetic code.Nucleic acids research · 2016Review
- Statistical analysis of pentose phosphate pathway genes from eubacteria and eukarya reveals translational selection as a major force in shaping codon usage pattern.Bioinformation · 2013Article
- Human Retrovirus Codon Usage from tRNA Point of View: Therapeutic Insights.Bioinformatics and biology insights · 2013Article
- On the organizational dynamics of the genetic code.Genomics, proteomics & bioinformatics · 2011Article
- A model-independent approach to infer hierarchical codon substitution dynamics.BMC bioinformatics · 2010Article
- Article
- A content-centric organization of the genetic code.Genomics, proteomics & bioinformatics · 2007Article
- Common patterns in type II restriction enzyme binding sites.Nucleic acids research · 2005Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Since the early days of the discovery of the genetic code nonrandom patterns have been searched for in the code in the hope of providing information about its origin and early evolution. Here we present a new classification scheme of the genetic code that is based on a binary representation of the purines and pyrimidines. This scheme reveals known patterns more clearly than the common one, for instance, the classification of strong, mixed, and weak codons as well as the ordering of codon families. Furthermore, new patterns have been found that have not been described before: Nearly all quantitative amino acid properties, such as Woese's polarity and the specific volume, show a perfect correlation to Lagerkvist's codon-anticodon binding strength. Our new scheme leads to new ideas about the evolution of the genetic code. It is hypothesized that it started with a binary doublet code and developed via a quaternary doublet code into the contemporary triplet code. Furthermore, arguments are presented against suggestions that a "simpler" code, where only the midbase was informational, was at the origin of the genetic code.
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