ArticleNaunyn-Schmiedeberg's archives of pharmacology2005
17beta-Estradiol inhibits calcium-dependent, but not calcium-independent, contraction in isolated rat aorta.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Estrogen and its role in gastrointestinal health and disease.International journal of colorectal disease · 2009Review
- 17beta-estradiol attenuates vascular contraction through inhibition of RhoA/Rho kinase pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is now well known that 17beta-estradiol has an endothelium-independent, non-genomic vasorelaxant effect. We hypothesized that 17beta-estradiol has its non-genomic effect on calcium-independent contraction in de-endothelialized rat aortic rings. Rat aortic ring preparations were mounted in organ baths and exposed to contractile agents. 17beta-Estradiol (8, 20 or 50 microM), but not 17alpha-estradiol, concentration-dependently decreased the tension induced by 1.0 microM phenylephrine (PE) in the presence, but not in the absence, of calcium in the solution. Pretreatment with 17beta-estradiol concentration-dependently inhibited vascular contractions induced by cumulative addition of PE or calcium and almost completely abolished those induced by cumulative addition of Bay K8644, a calcium channel opener. Furthermore, 17beta-estradiol also concentration-dependently decreased the tension induced by 0.3 microM phorbol 12,13-dibutyrate (PDBu), a protein kinase C activator, in the presence of calcium in the solution, but not in the absence of calcium in the solution. Pretreatment with 17beta-estradiol had little effect on vascular contractions induced by PDBu or PE or on PE-induced mitogen-activated protein kinase (MAPK) activation in calcium-free Krebs solution. These results suggest that 17beta-estradiol inhibits calcium-dependent, but not calcium-independent, vascular contraction.
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