ArticleApplied and environmental microbiology2005
Transcriptional organization of genes for protocatechuate and quinate degradation from Acinetobacter sp. strain ADP1.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 30 citations in OpenAlex.
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- Metabolism of aromatics by Trichosporon oleaginosus while remaining oleaginous.Microbial cell factories · 2017Article
- How Aromatic Compounds Block DNA Binding of HcaR Catabolite Regulator.The Journal of biological chemistry · 2016Article
- Arhodomonas sp. strain Seminole and its genetic potential to degrade aromatic compounds under high-salinity conditions.Applied and environmental microbiology · 2014Article
- Novel metabolic features inMetabolomics : Official journal of the Metabolomic Society · 2014Article
- Transcriptional regulation of the terephthalate catabolism operon in Comamonas sp. strain E6.Applied and environmental microbiology · 2010Article
- Uncovering the protocatechuate 2,3-cleavage pathway genes.Journal of bacteriology · 2009Article
- Regulation of expression of genes involved in quinate and shikimate utilization in Corynebacterium glutamicum.Applied and environmental microbiology · 2009Article
- Role of Acinetobacter baylyi Crc in catabolite repression of enzymes for aromatic compound catabolism.Journal of bacteriology · 2009Article
- Article
- Multiple-level regulation of genes for protocatechuate degradation in Acinetobacter baylyi includes cross-regulation.Applied and environmental microbiology · 2007Article
- Transcriptional organization and regulation of magnetosome operons in Magnetospirillum gryphiswaldense.Applied and environmental microbiology · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quinate and protocatechuate are both abundant plant products and can serve, along with a large number of other aromatic or hydroaromatic compounds, as growth substrates for Acinetobacter sp. strain ADP1. The respective genes are part of the chromosomal dca-pca-qui-pob-hca cluster encoding these pathways. The adjacent pca and qui gene clusters, which encode enzymes for protocatechuate breakdown via the beta-ketoadipate pathway and for the conversion of quinate or shikimate to protocatechuate, respectively, have the same direction of transcription and are both expressed inducibly in response to protocatechuate. The pca genes are governed by the transcriptional activator-repressor PcaU. The mechanism governing qui gene expression was previously unknown. Here we report data suggesting the existence of a large 14-kb primary transcript covering the pca and qui genes. The area between the pca and qui genes contains no promoter activity, whereas a weak, constitutive promoter was identified upstream of quiA (quiAp). The 5' end of the quiA transcript was mapped. Northern blot analysis allowed the identification of a 12-kb transcript spanning pcaI to quiX. An analysis of the pca and qui gene transcripts in a strain missing the structural gene promoter pcaIp led to the identification of two pcaIp-independent transcripts (4 and 2.4 kb). The 2.4-kb transcript makes up about 25% of the total transcript abundance of quiA, and thus the majority of transcription of the last gene of the area is also driven by pcaIp. This report strongly supports the organization of the pca and qui genes as a pca-qui operon and, furthermore, suggests that PcaU is the regulator governing its expression.
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