ArticleNucleic acids research2005
The splicing regulatory element, UGCAUG, is phylogenetically and spatially conserved in introns that flank tissue-specific alternative exons.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 103 citations in OpenAlex.
- Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is altered in striated muscle diseases.RNA biology · 2025Article
- Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells.Journal of molecular cell biology · 2024Article
- Splicing regulation of GFPT1 muscle-specific isoform and its roles in glucose metabolisms and neuromuscular junction.iScience · 2023Article
- Hypoplastic Left Heart Syndrome: Signaling & Molecular Perspectives, and the Road Ahead.International journal of molecular sciences · 2023Review
- RBFOX2-regulated TEAD1 alternative splicing plays a pivotal role in Hippo-YAP signaling.Nucleic acids research · 2022Article
- Systematic characterization of short intronic splicing-regulatory elements in SMN2 pre-mRNA.Nucleic acids research · 2022Article
- Using secondary structure to predict the effects of genetic variants on alternative splicing.Human mutation · 2019Article
- Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN.Human molecular genetics · 2018Article
- Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish.Developmental biology · 2017Article
- Developmental regulation of RNA processing by Rbfox proteins.Wiley interdisciplinary reviews. RNA · 2017Review
- Rbfox2 function in RNA metabolism is impaired in hypoplastic left heart syndrome patient hearts.Scientific reports · 2016Article
- Splicing predictions reliably classify different types of alternative splicing.RNA (New York, N.Y.) · 2015Article
- RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing.Nature structural & molecular biology · 2014Article
- HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism.Cell reports · 2014Article
- Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges.Nature structural & molecular biology · 2013Article
- Control of neuronal voltage-gated calcium ion channels from RNA to protein.Trends in neurosciences · 2013Review
- Rare inherited A2BP1 deletion in a proband with autism and developmental hemiparesis.American journal of medical genetics. Part A · 2012Article
- Mutually exclusive splicing regulates the Nav 1.6 sodium channel function through a combinatorial mechanism that involves three distinct splicing regulatory elements and their ligands.Nucleic acids research · 2012Article
- VERSE: a varying effect regression for splicing elements discovery.Journal of computational biology : a journal of computational molecular cell biology · 2012Article
- Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity.Cancer research · 2012Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have identified UGCAUG as an intron splicing enhancer that is frequently located adjacent to tissue-specific alternative exons in the human genome. Here, we show that UGCAUG is phylogenetically and spatially conserved in introns that flank brain-enriched alternative exons from fish to man. Analysis of sequence from the mouse, rat, dog, chicken and pufferfish genomes revealed a strongly statistically significant association of UGCAUG with the proximal intron region downstream of brain-enriched alternative exons. The number, position and sequence context of intronic UGCAUG elements were highly conserved among mammals and in chicken, but more divergent in fish. Control datasets, including constitutive exons and non-tissue-specific alternative exons, exhibited a much lower incidence of closely linked UGCAUG elements. We propose that the high sequence specificity of the UGCAUG element, and its unique association with tissue-specific alternative exons, mark it as a critical component of splicing switch mechanism(s) designed to activate a limited repertoire of splicing events in cell type-specific patterns. We further speculate that highly conserved UGCAUG-binding protein(s) related to the recently described Fox-1 splicing factor play a critical role in mediating this specificity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.