Evidence map›Paper›PMID 15690603›Full record

ReviewPeptides2005

A walk-through of the yeast mating pheromone response pathway.

Lee Bardwell

Abstract readReviewCorrected and Republished Article
In one paragraph

Review in Peptides, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

184 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Kar4 acts as a Ste12 regulator inbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. A yeast mating platform for multiplex screening of fungal GPCR-ligand interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. STRIPAK, a fundamental signaling hub of eukaryotic development.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Design patterns of biological cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Review

124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Lee BardwellDepartment of Developmental and Cell Biology, 2208 Natural Sciences I, University of California, Irvine, CA 92697-2300, USA. bardwell@uci.edu

Funding

MAP KINASE CASCADE SIGNAL TRANSMISSION AND SPECIFICITYR01GM060366 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARDWELL, LEE S · 2000 to 2008
$2.2M
A signal transduction pathway database/modeling systemR33GM069013 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MJOLSNESS, ERIC D · 2004 to 2006
$1.7M
A signal transduction pathway database/modeling systemR21GM069013 · NIGMS · UNIVERSITY OF CALIFORNIA IRVINE · PI MJOLSNESS, ERIC D · 2003 to 2003
$157k
NIGMS NIH HHS GM60366NIGMS NIH HHS GM69013NIGMS NIH HHS R01 GM060366NIGMS NIH HHS R21 GM069013NIGMS NIH HHS R33 GM069013
6 · The paper itself

Abstract

The intracellular signal transduction pathway by which the yeast Saccharomyces cerevisiae responds to the presence of peptide mating pheromone in its surroundings is one of the best understood signaling pathways in eukaryotes, yet continues to generate new surprises and insights. In this review, we take a brief walk down the pathway, focusing on how the signal is transmitted from the cell-surface receptor-coupled G protein, via a MAP kinase cascade, to the nucleus.

Indexed as

Signal TransductionCell CycleCell MembraneGTP-Binding ProteinsMAP Kinase Kinase KinasesMAP Kinase Signaling SystemModels, BiologicalPheromonesReceptors, Cell SurfaceSaccharomyces cerevisiaeGTP-Binding ProteinsMAP Kinase Kinase KinasesPheromonesReceptors, Cell Surface

Identifiers

PMID15690603
PMCPMC3017506

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.