ReviewThe Journal of clinical investigation2005
Defining smooth muscle cells and smooth muscle injury.
Review in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape.Journal of the American Heart Association · 2020Pooled it
- Skeletal muscle Nur77 and NOR1 insulin responsiveness is blunted in obesity and type 2 diabetes but improved after exercise training.Physiological reports · 2019Trial
- Heterogenous microglial reactivity contrasts with stable vascular transcriptional programs in mouse models of Alzheimer's, CADASIL, and Traumatic Brain Injury.Nature communications · 2026Article
- YY1 regulates vascular resistance and blood pressure dynamics through epigenetic control of m6A RNA modifications in vascular smooth muscle cells.Cardiovascular research · 2025Article
- Live Observation of Atherosclerotic Plaque Disruption in Apolipoprotein E-Deficient Mouse.Ultrasound international open · 2015Article
- Loss of the mechanotransducer zyxin promotes a synthetic phenotype of vascular smooth muscle cells.Journal of the American Heart Association · 2015Article
- Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells.Journal of the American Heart Association · 2014Article
- Differentiation of smooth muscle progenitor cells in peripheral blood and its application in tissue engineered blood vessels.Journal of Zhejiang University. Science. B · 2008Article
- Microarray gene profiling of laser-captured cells: a new tool to study atherosclerosis in mice.Atherosclerosis · 2008Article
- Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cells.Circulation research · 2008Article
- Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells.The Journal of clinical investigation · 2006Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
For 3 decades, terms such as synthetic phenotype and contractile phenotype have been used to imply the existence of a specific mechanism for smooth muscle cell (SMC) responses to injury. In this issue of the JCI, Hendrix et al. offer a far more precise approach to examining the mechanisms of SMC responses to injury, focused not on general changes in phenotype but on effects of injury on a single promoter element, the CArG [CC(A/T)6GG] box, in a single gene encoding smooth muscle (SM) alpha-actin. Since CArG box structures are present in some, but not all, SMC genes, these data suggest that we may be progressing toward establishing a systematic, molecular classification of both SMC subsets and the response of SMCs to different injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.