ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
NMDA receptor currents suppress synapse formation on sprouting axons in vivo.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
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- Effects of Anti-NMDA Antibodies on Functional Recovery and Synaptic Rearrangement Following Hemicerebellectomy.Neuromolecular medicine · 2016Article
- Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine.Neuroscience · 2015Article
- Neurodevelopmental implications of the general anesthesia in neonate and infants.Experimental neurology · 2015Review
- Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.Molecular pharmacology · 2015Review
- Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia.Neuropharmacology · 2015Article
- Prenatal inhibition of the kynurenine pathway leads to structural changes in the hippocampus of adult rat offspring.The European journal of neuroscience · 2014Article
- AMPA-silent synapses in brain development and pathology.Nature reviews. Neuroscience · 2013Review
- Glycine transporter-1 inhibition promotes striatal axon sprouting via NMDA receptors in dopamine neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Prenatal activation of Toll-like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis markers in offspring.Molecular brain · 2012Article
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- Local Ca2+ detection and modulation of synaptic release by astrocytes.Nature neuroscience · 2011Article
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- PDZ protein mediated activity-dependent LTP/LTD developmental switch at rat retinocollicular synapses.American journal of physiology. Cell physiology · 2010Article
- Silent synapses in developing rat nucleus tractus solitarii have AMPA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- NMDA receptors inhibit synapse unsilencing during brain development.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
NMDA receptors (NMDARs) play an important role in the structural maintenance and functional strength of synapses. The causal relationship between these anatomical and functional roles is poorly defined. Using quantitative confocal microscopy, synaptic vesicle immunoreactivity, and differential label of retinal projections, we measured axon volume and synapse density along ipsilateral retinal axons (ipsi axons) sprouting into the superficial visual layers of the superior colliculus (sSC) deafferented by a contralateral retinal lesion (a scotoma) 8 d earlier. When retinal lesions were made at postnatal day 6 (P6), glutamatergic synaptic currents on neurons within the scotoma were significantly reduced. Both ipsi axon sprouting and synapse density were increased by chronic d-AP-5 antagonism of NMDARs. Conversely, ipsi axon sprouting and synapse density were reduced by chronic exposure to the agonist, NMDA, known to functionally depress glutamate transmission in this system. After P11 lesions, however, NMDAR blockade had no effect on sprouting or synapse density. Developmental changes in NMDAR current kinetics could not account for this difference in the structural effects of NMDAR function. Also, synaptic current frequencies within the scotoma were not affected after the P11 lesions. The corticocollicular projection matures during the P11 survival interval and, as indicated by previous work, it is a source of competition for synaptic space and probably of maintained activity in the older sSC. Thus, our results suggest that during early development, NMDAR currents predominantly destabilize nascent synapses. As the neuropil matures, however, competition for synaptic space suppresses axon sprouting and synapse formation regardless of NMDAR function.
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