ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Changes of internal state are expressed in coherent shifts of neuromuscular activity in Aplysia feeding behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
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- Cellular Effects of Repetition Priming in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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- Specificity of repetition priming: the role of chemical coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Neuromodulation as a mechanism for the induction of repetition priming.Current opinion in neurobiology · 2014Review
- Motor circuit-specific burst patterns drive different muscle and behavior patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Extracellularly identifying motor neurons for a muscle motor pool in Aplysia californica.Journal of visualized experiments : JoVE · 2013Article
- Variables controlling entry into and exit from the steady-state, one of two modes of feeding in Aplysia.PloS one · 2012Article
- Functional organization and adaptability of a decision-making network in aplysia.Frontiers in neuroscience · 2012Article
- Repetition priming of motoneuronal activity in a small motor network: intercellular and intracellular signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Composite modulatory feedforward loop contributes to the establishment of a network state.Journal of neurophysiology · 2010Article
- Motor outputs in a multitasking network: relative contributions of inputs and experience-dependent network states.Journal of neurophysiology · 2009Article
- State dependence of network output: modeling and experiments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Review
- An input-representing interneuron regulates spike timing and thereby phase switching in a motor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Predicting adaptive behavior in the environment from central nervous system dynamics.PloS one · 2008Article
- State dependence of spike timing and neuronal function in a motor pattern generating network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Behavioral and in vitro correlates of compulsive-like food seeking induced by operant conditioning in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- From hunger to satiety: reconfiguration of a feeding network by Aplysia neuropeptide Y.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Variability of motor neuron spike timing maintains and shapes contractions of the accessory radula closer muscle of Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multitasking central pattern generator (CPG) that drives consummatory feeding behaviors of Aplysia can produce ingestive, egestive, and intermediate motor programs. External stimuli trigger the programs but, remarkably, do not directly specify which type of program is produced. Rather, recent work has proposed, the type of program is determined by the internal network state of the CPG that has developed in response to the previous history of the stimulation. Here we have tested a key prediction of this network-state hypothesis. If the network state has a real existence and governs real functional behavior, changes in the state should be seen as coherent, coordinated changes along many dimensions of interneuron and motor neuron activity, muscle contraction, and ultimately movement, that underlie functional behavior. In reduced neuromuscular preparations, we elicited repetitive motor programs by continued stimulation of the esophageal nerve while recording the firing of motor neurons B8, B15, B16, B4/5, and B48, and contractions of the accessory radula closer and I7-I10 muscles that respectively close and open the animal's food-grasping organ, the radula. Using sonomicrometric techniques, we similarly recorded the movement of the radula in the complete buccal mass. Successive esophageal nerve programs indeed exhibited clear progressive changes in motor neuron firing, muscle contractions, and the phasing of radula movements within each cycle, from an initially intermediate or even ingestive character to a strongly egestive character. We conclude that the Aplysia feeding CPG really has a coherent internal network state whose dynamics are likely to be reflected in the real behavior of the animal.
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