ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Rapid activity-driven SNARE-dependent trafficking of nicotinic receptors on somatic spines.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Nicotinic Receptors in Human Chromaffin Cells: Characterization, Functional and Physical Interactions between Subtypes and Regulation.International journal of molecular sciences · 2024Review
- Genes and pathways co-associated with the exposure to multiple drugs of abuse, including alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine, and/or nicotine: a review of proteomics analyses.Molecular neurobiology · 2011Review
- Olfactory habituation: fresh insights from flies.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Postsynaptic scaffolds for nicotinic receptors on neurons.Acta pharmacologica Sinica · 2009Review
- Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery.The AAPS journal · 2009Review
- Mammalian nicotinic acetylcholine receptors: from structure to function.Physiological reviews · 2009Review
- EphB receptors co-distribute with a nicotinic receptor subtype and regulate nicotinic downstream signaling in neurons.Molecular and cellular neurosciences · 2008Article
- Water and ion channels: crucial in the initiation and progression of apoptosis in central nervous system?Current neuropharmacology · 2008Article
- Intracellular complexes of the beta2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Role of endogenous nicotinic signaling in guiding neuronal development.Biochemical pharmacology · 2007Review
- Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation.Biochemical pharmacology · 2007Article
- Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Dendritic Ca2+ signalling due to activation of alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal neurons.The Journal of physiology · 2007Article
- BDNF up-regulates alpha7 nicotinic acetylcholine receptor levels on subpopulations of hippocampal interneurons.Molecular and cellular neurosciences · 2006Article
- An acute effect of neuregulin 1 beta to suppress alpha 7-containing nicotinic acetylcholine receptors in hippocampal interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Apoptotic surface delivery of K+ channels.Cell death and differentiation · 2006Article
- Nicotinic signal transduction machinery.Journal of molecular neuroscience : MN · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Rapid trafficking of glutamate receptors contributes importantly to synaptic plasticity, but whether similar trafficking extends to other ionotropic receptors is unknown. Nicotinic acetylcholine receptors containing alpha7 subunits are widely expressed in the nervous system and allow calcium influx. Because of this, alpha7-containing receptors regulate diverse events, depending on the signaling pathways available. We find that the receptors codistribute with target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) postsynaptically and that nicotinic stimulation rapidly induces SNARE-dependent vesicular endocytosis accompanied by receptor internalization. At the same time, a SNARE-dependent process recruits receptors to the cell surface from internal pools. Overall, the trafficking does not markedly change the number of surface receptors or their combined whole-cell response to nicotine. SNARE-dependent trafficking is needed, however, for the receptors to remain capable of activating the transcription factor cAMP response element-binding protein and attendant gene expression when repeatedly challenged. Thus, trafficking appears to be essential for maintaining functional coupling between alpha7-receptor responses and downstream signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.