SynthesisInternational archives of occupational and environmental health2004
Prostate cancer among pesticide applicators: a meta-analysis.
Synthesis in International archives of occupational and environmental health, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Cancer and occupational exposure to pesticides: an umbrella review.International archives of occupational and environmental health · 2021Pooled it
- Body concentrations of persistent organic pollutants and prostate cancer: a meta-analysis.Environmental science and pollution research international · 2015Pooled it
- Cancer risks in a population-based study of agricultural workers: results from the Taiwan's Farmers and Health Cohort study.Scandinavian journal of work, environment & health · 2023Article
- Combined Effects of Different Endocrine-Disrupting Chemicals (EDCs) on Prostate Gland.International journal of environmental research and public health · 2021Review
- Pesticide exposure and risk of aggressive prostate cancer among private pesticide applicators.Environmental health : a global access science source · 2020Article
- Occupational Risk Factors for Prostate Cancer: A Meta-analysis.Journal of cancer prevention · 2019Review
- Risk of early-onset prostate cancer associated with occupation in the Nordic countries.European journal of cancer (Oxford, England : 1990) · 2017Article
- Pesticide Exposure and Head and Neck Cancers: A Case-Control Study in an Agricultural Region.Iranian journal of otorhinolaryngology · 2017Article
- Cancer incidence in the AGRICAN cohort study (2005-2011).Cancer epidemiology · 2017Article
- Sex Steroid Hormone Single-Nucleotide Polymorphisms, Pesticide Use, and the Risk of Prostate Cancer: A Nested Case-Control Study within the Agricultural Health Study.Frontiers in oncology · 2016Article
- DNA damage in B and T lymphocytes of farmers during one pesticide spraying season.International archives of occupational and environmental health · 2015Article
- Prediagnostic Serum Organochlorine Concentrations and Metastatic Prostate Cancer: A Nested Case-Control Study in the Norwegian Janus Serum Bank Cohort.Environmental health perspectives · 2015Article
- Brain cancer mortality in an agricultural and a metropolitan region of Rio de Janeiro, Brazil: a population-based, age-period-cohort study, 1996-2010.BMC cancer · 2014Article
- Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Risk of total and aggressive prostate cancer and pesticide use in the Agricultural Health Study.American journal of epidemiology · 2013Article
- Article
- Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk.Carcinogenesis · 2012Article
- Occupational pesticide exposures and cancer risk: a review.Journal of toxicology and environmental health. Part B, Critical reviews · 2012Review
- Endocrine-disrupting chemicals: associated disorders and mechanisms of action.Journal of environmental and public health · 2012Review
- The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk.Journal of cancer epidemiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo analyse data from peer-reviewed, case-referent and cohort studies, studying the occurrence of prostate cancer in pesticide applicators and in some other, related, occupational categories, in order to determine a possible relationship of cancer of the prostate with pesticide exposure; to calculate a meta-rate ratio and to compare it with the meta-rate ratios obtained in a previous meta-analysis performed over a shorter time (1995-2001) in a broader exposure category, including many pesticide-related agricultural and non-agricultural occupations.
methodsMedline was searched for the years between 1966 and 2003, and relevant studies were identified from 1986 on. We conducted a meta-analysis of 22 studies complying with the inclusion criteria in order to pool their relative risk (RR) estimates. Studies were summarised and assessed for homogeneity and publication bias.
resultsThe meta-rate ratio, based on 22 estimates of RR, is 1.24 [95% confidence interval (95% CI) 1.06-1.45]. This pooled risk estimate for the occupational categories selected is higher than the one previously calculated for farmers in general over a shorter period of publication. Substantial heterogeneity of rate ratios exists between the different studies. The major source of heterogeneity identified is geographic location. Increased meta-rate ratios are observed for studies derived from North America as well as from Europe, the meta-rate ratios from Europe being lower than those from North America. There is no obvious indication of publication bias.
conclusionThe increased meta-rate ratio for prostate cancer in agricultural pesticide applications provides additional evidence for a possible relationship between pesticide exposure and prostate cancer. The homogeneity observed between the individual rate ratios, after we had regrouped the data according to geographic location, tends to increase the consistency of the association. However, the data available from the individual studies do not provide sufficient exposure information for firm conclusions to be drawn about pesticide exposure as the cause of prostate cancer, independently from other factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.