ReviewPflugers Archiv : European journal of physiology2005
Regulation of organic cation transport.
Review in Pflugers Archiv : European journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Interaction of the chemotherapeutic agent oxaliplatin and the tyrosine kinase inhibitor dasatinib with the organic cation transporter 2.Archives of toxicology · 2024Article
- Regulation of Transporters for Organic Cations by High Glucose.International journal of molecular sciences · 2023Article
- The determination of the effect(s) of solute carrier family 22-member 2 (SLC22A2) haplotype variants on drug binding via molecular dynamic simulation systems.Scientific reports · 2022Article
- Acute infusion of angiotensin II regulates organic cation transporters function in the kidney: its impact on the renal dopaminergic system and sodium excretion.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Drug-Drug Interactions at Organic Cation Transporter 1.Frontiers in pharmacology · 2021Review
- Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K.International journal of molecular sciences · 2020Article
- Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel.Biochemical pharmacology · 2018Article
- Whole body physiologically based modelling of β-blockers in the rat: events in tissues and plasma following an i.v. bolus dose.British journal of pharmacology · 2018Article
- Activation of liver X receptor inhibits OCT2-mediated organic cation transport in renal proximal tubular cells.Pflugers Archiv : European journal of physiology · 2017Article
- Uptake Assays to Monitor Anthracyclines Entry into Mammalian Cells.Bio-protocol · 2017Article
- Characterization of murine polyspecific monoamine transporters.FEBS open bio · 2017Article
- Regulation of Dopamine Uptake by Vasoactive Peptides in the Kidney.Scientifica · 2016Article
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- Blood brain barrier: a challenge for effectual therapy of brain tumors.BioMed research international · 2015Review
- Role of transporters in the distribution of platinum-based drugs.Frontiers in pharmacology · 2015Review
- Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules.Pflugers Archiv : European journal of physiology · 2014Article
- The organic cation transporter 3 (OCT3) as molecular target of psychotropic drugs: transport characteristics and acute regulation of cloned murine OCT3.Pflugers Archiv : European journal of physiology · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transport of organic cations (OC) is important for the recycling of endogenous OC and also a necessary step for detoxification of exogenous OC in the body. Even though the identification and characterisation of numerous OC transporters in recent years has allowed the elucidation of molecular mechanisms underlying OC transport, elucidation of the regulation of this transport is just beginning. This review summarises the general properties of OC transport and then analyses the literature on the regulation of these processes. Studies on short- and long-term regulation of OC transport are considered separately. Important aspects of short-term regulation have been clarified and the regulatory pathways of several OC transporters have been characterised. Short-term regulation appears to be transporter subtype-, tissue- and species-dependent and to involve transporter phosphorylation. Transporter phosphorylation may alter the affinity for substrates or/and expression on the plasma membrane. Even though several studies have shown long-term regulation of OC transport, the pathophysiological meaning of these changes are not well understood. In this case, regulation seems to be subtype-, tissue- and gender-specific. Further research is necessary to clarify this important issue of regulation of OC transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.