ArticleProceedings of the National Academy of Sciences of the United States of America2005
Complex early genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
72 citing papers in PubMed, 149 citations in OpenAlex.
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- Genome-wide identification and expression analysis of PERK genes in peanut and revelation of bidirectional immune regulatory function.Frontiers in plant science · 2025Article
- Phylogenetic Analysis of 590 Species Reveals Distinct Evolutionary Patterns of Intron-Exon Gene Structures Across Eukaryotic Lineages.Molecular biology and evolution · 2024Article
- Genome-wide identification and expression analysis of the cellulose synthase gene family in potato (Frontiers in plant science · 2024Article
- Genome-wide identification of theFrontiers in plant science · 2024Article
- Where the minor things are: a pan-eukaryotic survey suggests neutral processes may explain much of minor intron evolution.Nucleic acids research · 2023Article
- Genome-wide identification and expression analysis of the HD2 protein family and its response to drought and salt stress inFrontiers in plant science · 2023Article
- Intron losses and gains in the nematodes.Biology direct · 2022Article
- Identification, evolutionary analysis and functional diversification of RAV gene family in cotton (G. hirsutum L.).Planta · 2021Article
- ExOrthist: a tool to infer exon orthologies at any evolutionary distance.Genome biology · 2021Article
- Article
- Genome-Wide Identification and Evolutionary Analysis ofFrontiers in plant science · 2021Article
- Identification and Analysis ofFrontiers in plant science · 2021Article
- Genome-wide identification of GhAAI genes reveals that GhAAI66 triggers a phase transition to induce early flowering.Journal of experimental botany · 2019Article
- Identification of Histone H3 (Genes · 2019Article
- Genome-Wide Identification and Characterization of theInternational journal of molecular sciences · 2019Article
- Genome-wide analysis of GRAS transcription factor gene family in Gossypium hirsutum L.BMC genomics · 2018Article
- Splice Sites Seldom Slide: Intron Evolution in Oomycetes.Genome biology and evolution · 2016Article
- Synonymous codon usage bias in plant mitochondrial genes is associated with intron number and mirrors species evolution.PloS one · 2015Article
- Recurrent loss of specific introns during angiosperm evolution.PLoS genetics · 2014Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We use the pattern of intron conservation in 684 groups of orthologs from seven fully sequenced eukaryotic genomes to provide maximum likelihood estimates of the number of introns present in the same orthologs in various eukaryotic ancestors. We find: (i) intron density in the plant-animal ancestor was high, perhaps two-thirds that of humans and three times that of Drosophila; and (ii) intron density in the ancestral bilateran was also high, equaling that of humans and four times that of Drosophila. We further find that modern introns are generally very old, with two-thirds of modern bilateran introns dating to the ancestral bilateran and two-fifths of modern plant, animal, and fungus introns dating to the plant-animal ancestor. Intron losses outnumber gains over a large range of eukaryotic lineages. These results show that early eukaryotic gene structures were very complex, and that simplification, not embellishment, has dominated subsequent evolution.
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