ArticleProceedings of the National Academy of Sciences of the United States of America2005
Conserved patterns of protein interaction in multiple species.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 251 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
251 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- On the Origin of Biomolecular Networks.Frontiers in genetics · 2019Pooled it
- Conserved toxic responses across divergent phylogenetic lineages: a meta-analysis of the neurotoxic effects of RDX among multiple species using toxicogenomics.Ecotoxicology (London, England) · 2011Pooled it
- xBind: an integrated webserver for large language model-enabled cross-molecular protein binding site prediction.Nucleic acids research · 2026Article
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- Selection for Molecularly Complementary Modules (MCMs) Drives the Origins and Evolution of Pleiofunctional, Epistatic Interactomes (PEIs).Life (Basel, Switzerland) · 2026Review
- Co-Immunoprecipitation-Coupled Mass Spectrometry Analysis of Zyxin's Interactome and Phosphosites in EarlyInternational journal of molecular sciences · 2026Article
- Protein-Protein Interaction Site Prediction via EquiPPIS and Its Application in Studying Viral Replication.Methods in molecular biology (Clifton, N.J.) · 2026Article
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- INTREPPPID-an orthologue-informed quintuplet network for cross-species prediction of protein-protein interaction.Briefings in bioinformatics · 2024Article
- Robust, scalable, and informative clustering for diverse biological networks.Genome biology · 2023Article
- E(3) equivariant graph neural networks for robust and accurate protein-protein interaction site prediction.PLoS computational biology · 2023Article
- Gemini: memory-efficient integration of hundreds of gene networks with high-order pooling.Bioinformatics (Oxford, England) · 2023Article
- In silico analysis decodes transthyretin (TTR) binding and thyroid disrupting effects of per- and polyfluoroalkyl substances (PFAS).Archives of toxicology · 2023Article
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- Computational systems biology in disease modeling and control, review and perspectives.NPJ systems biology and applications · 2022Review
- Computational Network Inference for Bacterial Interactomics.mSystems · 2022Review
- Network approach to understand biological systems: From single to multilayer networks.Journal of biosciences · 2022Article
- Functional Analysis of Hypothetical Proteins ofBioinformatics and biology insights · 2022Article
- Functional Annotation of Hypothetical Proteins From theBioinformatics and biology insights · 2022Article
- Computationally Reconstructed Interactome ofInternational journal of molecular sciences · 2021Article
191 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To elucidate cellular machinery on a global scale, we performed a multiple comparison of the recently available protein-protein interaction networks of Caenorhabditis elegans, Drosophila melanogaster, and Saccharomyces cerevisiae. This comparison integrated protein interaction and sequence information to reveal 71 network regions that were conserved across all three species and many exclusive to the metazoans. We used this conservation, and found statistically significant support for 4,645 previously undescribed protein functions and 2,609 previously undescribed protein interactions. We tested 60 interaction predictions for yeast by two-hybrid analysis, confirming approximately half of these. Significantly, many of the predicted functions and interactions would not have been identified from sequence similarity alone, demonstrating that network comparisons provide essential biological information beyond what is gleaned from the genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.