ArticleGenetics2005
A genetic and molecular characterization of two proximal heterochromatic genes on chromosome 3 of Drosophila melanogaster.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Article
- Functions of HP1 proteins in transcriptional regulation.Epigenetics & chromatin · 2022Review
- Article
- Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes ineLife · 2020Article
- Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 inG3 (Bethesda, Md.) · 2019Article
- Article
- Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila.PLoS genetics · 2016Article
- Transcriptomic Analyses Reveal Novel Genes with Sexually Dimorphic Expression in Yellow Catfish (Pelteobagrus fulvidraco) Brain.Marine biotechnology (New York, N.Y.) · 2015Article
- The highly expressed methionine synthase gene of Neurospora crassa is positively regulated by its proximal heterochromatic region.Nucleic acids research · 2014Article
- Article
- HP1a, Su(var)3-9, SETDB1 and POF stimulate or repress gene expression depending on genomic position, gene length and expression pattern in Drosophila melanogaster.Nucleic acids research · 2013Article
- Juxtaposition of heterochromatic and euchromatic regions by chromosomal translocation mediates a heterochromatic long-range position effect associated with a severe neurological phenotype.Molecular cytogenetics · 2012Article
- dSet1 is the main H3K4 di- and tri-methyltransferase throughout Drosophila development.Genetics · 2012Article
- Chromatin: constructing the big picture.The EMBO journal · 2011Review
- Heterochromatin protein 1a is required for an open chromatin structure.Transcription · 2011Article
- Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome.Genome research · 2010Article
- Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2.Genetics · 2010Article
- Review
- High-resolution analysis of Drosophila heterochromatin organization using SuUR Su(var)3-9 double mutants.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterochromatin comprises a transcriptionally repressive chromosome compartment in the eukaryotic nucleus; this is exemplified by the silencing effect it has on euchromatic genes that have been relocated nearby, a phenomenon known as position-effect variegation (PEV), first demonstrated in Drosophila melanogaster. However, the expression of essential heterochromatic genes within these apparently repressive regions of the genome presents a paradox, an understanding of which could provide key insights into the effects of chromatin structure on gene expression. To date, very few of these resident heterochromatic genes have been characterized to any extent, and their expression and regulation remain poorly understood. Here we report the cloning and characterization of two proximal heterochromatic genes in D. melanogaster, located deep within the centric heterochromatin of the left arm of chromosome 3. One of these genes, RpL15, is uncharacteristically small, is highly expressed, and encodes an essential ribosomal protein. Its expression appears to be compromised in a genetic background deficient for heterochromatin protein 1 (HP1), a protein associated with gene silencing in these regions. The second gene in this study, Dbp80, is very large and also appears to show a transcriptional dependence upon HP1; however, it does not correspond to any known lethal complementation group and is likely to be a nonessential gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.