ArticleGenetics2005
Drosophila couch potato mutants exhibit complex neurological abnormalities including epilepsy phenotypes.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti.Nature ecology & evolution · 2025Article
- Single-cell type analysis of wing premotor circuits in the ventral nerve cord ofbioRxiv : the preprint server for biology · 2025Article
- Single-cell RNA sequencing of mid-to-late stage spider embryos: new insights into spider development.BMC genomics · 2024Article
- Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction.Nature communications · 2021Article
- Genetic Networks Underlying Natural Variation in Basal and Induced Activity Levels inG3 (Bethesda, Md.) · 2020Article
- Gene expression atlas of a developing tissue by single cell expression correlation analysis.Nature methods · 2019Article
- RNA-binding protein Rbpms is represented in human retinas by isoforms A and C and its transcriptional regulation involves Sp1-binding site.Molecular genetics and genomics : MGG · 2018Article
- Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family.RNA (New York, N.Y.) · 2017Article
- Article
- Drosophila sodium channel mutations: Contributions to seizure-susceptibility.Experimental neurology · 2015Review
- Article
- Genome-wide screen for modifiers of Na (+) /K (+) ATPase alleles identifies critical genetic loci.Molecular brain · 2014Article
- Drosophila as a model for intractable epilepsy: gilgamesh suppresses seizures in para(bss1) heterozygote flies.G3 (Bethesda, Md.) · 2013Article
- Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Article
- Elevated couch potato transcripts associated with adult diapause in the mosquito Culex pipiens.Journal of insect physiology · 2011Article
- Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies.Nature genetics · 2011Article
- Seizure and epilepsy: studies of seizure disorders in Drosophila.International review of neurobiology · 2011Review
- RNA binding protein with multiple splicing: a new marker for retinal ganglion cells.Investigative ophthalmology & visual science · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA-binding proteins play critical roles in regulation of gene expression, and impairment can have severe phenotypic consequences on nervous system function. We report here the discovery of several complex neurological phenotypes associated with mutations of couch potato (cpo), which encodes a Drosophila RNA-binding protein. We show that mutation of cpo leads to bang-sensitive paralysis, seizure susceptibility, and synaptic transmission defects. A new cpo allele called cpo(EG1) was identified on the basis of a bang-sensitive paralytic mutant phenotype in a sensitized genetic background (sda/+). In heteroallelic combinations with other cpo alleles, cpo(EG1) shows an incompletely penetrant bang-sensitive phenotype with approximately 30% of flies becoming paralyzed. In response to electroconvulsive shock, heteroallelic combinations with cpo(EG1) exhibit seizure thresholds less than half that of wild-type flies. Finally, cpo flies display several neurocircuit abnormalities in the giant fiber (GF) system. The TTM muscles of cpo mutants exhibit long latency responses coupled with decreased following frequency. DLM muscles in cpo mutants show drastic reductions in following frequency despite exhibiting normal latency relationships. The labile sites appear to be the electrochemical GF-TTMn synapse and the chemical PSI-DLMn synapses. These complex neurological phenotypes of cpo mutants support an important role for cpo in regulating proper nervous system function, including seizure susceptibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.