ArticleGenetics2005
Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- The genetic architecture of behavioral canalization.Trends in genetics : TIG · 2023Review
- Epistasis for head morphology in Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
- Integration of evidence across human and model organism studies: A meeting report.Genes, brain, and behavior · 2021Review
- Evolution of Epistatic Networks and the Genetic Basis of Innate Behaviors.Trends in genetics : TIG · 2020Review
- The complex underpinnings of genetic background effects.Nature communications · 2018Article
- Why does the magnitude of genotype-by-environment interaction vary?Ecology and evolution · 2018Review
- Advancing behavioural genomics by considering timescale.Nature communications · 2018Review
- Article
- Epistatic partners of neurogenic genes modulate Drosophila olfactory behavior.Genes, brain, and behavior · 2016Article
- Laboratory evolution of adenylyl cyclase independent learning in Drosophila and missing heritability.Genes, brain, and behavior · 2014Article
- Extensive epistasis for olfactory behaviour, sleep and waking activity in Drosophila melanogaster.Genetics research · 2012Article
- What is complex about complex disorders?Genome biology · 2012Article
- Genes involved in sex pheromone discrimination in Drosophila melanogaster and their background-dependent effect.PloS one · 2012Article
- Making scents of behavioural genetics: lessons from Drosophila.Genetics research · 2010Review
- Mutations and quantitative genetic variation: lessons from Drosophila.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- The role of genetic variation in the causation of mental illness: an evolution-informed framework.Molecular psychiatry · 2009Review
- The genetics of quantitative traits: challenges and prospects.Nature reviews. Genetics · 2009Review
- The Drosophila foraging gene mediates adult plasticity and gene-environment interactions in behaviour, metabolites, and gene expression in response to food deprivation.PLoS genetics · 2009Article
- Reliable neuromodulation from circuits with variable underlying structure.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Genetic architecture of quantitative traits in mice, flies, and humans.Genome research · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene interactions are emerging as central to understanding the realization of any phenotype. To probe the flexibility of interactions in a defined gene network, we isolated a set of 16 interacting genes in Drosophila, on the basis of their alteration of a quantitative behavioral phenotype-the loss of coordination in a temperature-sensitive allele of Syntaxin1A. The interactions inter se of this set of genes were then assayed in the presence and in the absence of the original Syntaxin1A mutation to ask whether the relationships among the 16 genes remain stable or differ after a change in genetic context. The pattern of epistatic interactions that occurs within this set of variants is dramatically altered in the two different genetic contexts. The results imply considerable flexibility in the network interactions of genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.