ArticleGenetics2005
Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogaster.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Article
- Using inbreeding to test the contribution of non-additive genetic effects to additive genetic variance: a case study inProceedings. Biological sciences · 2023Article
- A single-nucleotide change underlies the genetic assimilation of a plastic trait.Science advances · 2021Article
- Extensive genetic differentiation between recently evolved sympatric Arctic charr morphs.Ecology and evolution · 2019Article
- Article
- Natural Genetic Variation and Candidate Genes for Morphological Traits in Drosophila melanogaster.PloS one · 2016Article
- Abundance and distribution of transposable elements in two Drosophila QTL mapping resources.Molecular biology and evolution · 2013Article
- Article
- The Measurement of Local Variation in Shape.Evolutionary biology · 2012Article
- ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero.PloS one · 2012Article
- Population genomics of wild and laboratory zebrafish (Danio rerio).Molecular ecology · 2011Article
- Developmental stability: a major role for cyclin G in drosophila melanogaster.PLoS genetics · 2011Article
- Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn²⁺/(HCO₃⁻)₂ transporter expression.Biochemical and biophysical research communications · 2011Article
- Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation.BMC developmental biology · 2011Article
- Getting real with real-time qPCR: a case study of reference gene selection for morphological variation in Drosophila melanogaster wings.Development genes and evolution · 2011Article
- Article
- Association mapping in outbred populations: power and efficiency when genotyping parents and phenotyping progeny.Genetics · 2009Article
- Intraspecific evolution of the intercellular signaling network underlying a robust developmental system.Genes & development · 2008Article
- The genetic architecture of complex traits in teosinte (Zea mays ssp. parviglumis): new evidence from association mapping.Genetics · 2008Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Linkage disequilibrium mapping has been used extensively in medical and evolutionary genetics to map causal polymorphisms within genes associated with disease status or phenotypic variation for a trait. However, the initial findings of most nonhuman studies have not been replicated in subsequent studies, due in part to false positives, as well as additional factors that can render true positives unreplicable. These factors may be more severe when the initial study is performed using an experimental population of organisms reared under controlled lab conditions. We demonstrate that despite considerable phenotypic differences for wing shape between a lab-reared experimental population and a wild-caught cohort of Drosophila melanogaster, an association between a putative regulatory polymorphism in Egfr and wing shape can be replicated. These results are discussed both within the framework of future association-mapping studies and within the context of the evolutionary dynamics of alleles in populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.