ArticleGenetics2005
Costly resistance to parasitism: evidence from simultaneous quantitative trait loci mapping for resistance and fitness in Tribolium castaneum.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- The TapewormPathogens (Basel, Switzerland) · 2022Review
- Artificial selection reveals the role of transcriptional constraints in the maintenance of life history variation.Evolution letters · 2020Article
- Context-dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host.Ecology and evolution · 2018Article
- Behavioral, physiological and morphological correlates of parasite intensity in the wild Cururu toad (International journal for parasitology. Parasites and wildlife · 2017Article
- Fine-scale analysis of parasite resistance genes in the red flour beetle, Tribolium castaneum.Genetics · 2013Article
- Coevolving parasites and population size shape the evolution of mating behaviour.BMC evolutionary biology · 2013Article
- The costs of evolving resistance in heterogeneous parasite environments.Proceedings. Biological sciences · 2012Article
- Using experimental evolution to explore natural patterns between bacterial motility and resistance to bacteriophages.The ISME journal · 2011Article
- Antagonistic coevolution with parasites maintains host genetic diversity: an experimental test.Proceedings. Biological sciences · 2011Article
- Immunity in a variable world.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Infections with immunogenic trypanosomes reduce tsetse reproductive fitness: potential impact of different parasite strains on vector population structure.PLoS neglected tropical diseases · 2008Article
- Comparative genomic analysis of the Tribolium immune system.Genome biology · 2007Article
- Quantitative trait loci with age-specific effects on fecundity in Drosophila melanogaster.Genetics · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Information on the molecular basis of resistance and the evolution of resistance is crucial to an understanding of the appearance, spread, and distribution of resistance genes and of the mechanisms of host adaptation in natural populations. One potential important genetic constraint for the evolution of resistance is fitness cost associated with resistance. To determine whether host resistance to parasite infection is associated with fitness costs, we conducted simultaneous quantitative trait loci (QTL) mapping of resistance to parasite infection and fitness traits using the red flour beetle (Tribolium castaneum) and the tapeworm parasite (Hymenolepis diminuta) system in two independent segregating populations. A genome-wide QTL scan using amplified fragment length polymorphism (AFLP) markers revealed three QTL for beetle resistance to tapeworm infection. These three QTL account for 44-58% variance in beetle infection intensity. We identified five QTL for fecundity and five QTL for egg-to-adult viability, which accounted for 36-57% and 36-49%, respectively, of the phenotypic variance in fecundity and egg-to-adult viability. The three QTL conferring resistance were colocalized with the QTL affecting beetle fitness. The genome regions that contain the QTL for parasite resistance explained the majority of the variance in fecundity and egg-to-adult viability in the mapping populations. Colocalization of QTL conferring resistance to parasite infection and beetle fitness may result from the pleiotropic effects of the resistance genes on host fitness or from tight linkages between resistance genes and adverse deleterious mutations. Therefore, our results provide evidence that the genome regions conferring resistance to tapeworm infection are partially responsible for fitness costs in the resistant beetle populations.
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