ArticleJournal of feline medicine and surgery2005
Clinical, pathological and immunohistochemical study of feline mammary fibroepithelial hyperplasia following a single injection of depot medroxyprogesterone acetate.
Article in Journal of feline medicine and surgery, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 124 citations in OpenAlex.
- Feline mammary hyperplasia: A comparative study of medical versus surgical treatment approaches.Open veterinary journal · 2026Article
- Feline Mammary Tumors: A Comprehensive Review of Histological Classification Schemes, Grading Systems, and Prognostic Factors.Veterinary sciences · 2025Review
- Mammary carcinoma in a male cat following long-term medroxyprogesterone acetate treatment: case report and review of the literature.Veterinary research communications · 2024Review
- Recurrent Feline Mammary Fibroadenomatous Hyperplasia in a Cat During Gestation.Veterinary medicine and science · 2024Article
- Reversible Control of Reproduction In Queens: Mastering the use of reproductive drugs to manipulate cyclicity.Journal of feline medicine and surgery · 2022Review
- Feline breeding and pregnancy management: What is normal and when to intervene.Journal of feline medicine and surgery · 2022Review
- Effectiveness of ovariohysterectomy on feline mammary fibroepithelial hyperplasia treatment.Journal of feline medicine and surgery · 2021Article
- Effect of deslorelin on testicular function, serum dihydrotestosterone and oestradiol concentrations during and after suppression of sexual activity in tom cats.Journal of feline medicine and surgery · 2017Article
- Effect of melatonin on the reproductive cycle in female cats: a review of clinical experiences and previous studies.Journal of feline medicine and surgery · 2017Review
- Progestins to control feline reproduction: Historical abuse of high doses and potentially safe use of low doses.Journal of feline medicine and surgery · 2015Review
- Sequence variants and haplotype analysis of cat ERBB2 gene: a survey on spontaneous cat mammary neoplastic and non-neoplastic lesions.International journal of molecular sciences · 2012Article
- Feline reproduction: problems and clinical challenges.Journal of feline medicine and surgery · 2011Review
- Progesterone intoxication inducing marked sedation in a cat.Journal of feline medicine and surgery · 2010Article
- Reproduction control in cats: new developments in non-surgical methods.Journal of feline medicine and surgery · 2010Review
- Early detection, aggressive therapy: optimizing the management of feline mammary masses.Journal of feline medicine and surgery · 2010Review
- Mammary adenocarcinomas in three male cats exposed to medroxyprogesterone acetate (1990-2006).Journal of feline medicine and surgery · 2010Article
- Gynaecomastia in a male neutered cat with an adrenal tumour and associated hyperprogesteronism, hypercortisolism and hyperaldosteronism.JFMS open reportsArticle
- Mammary fibroadenomatous hyperplasia in a male cat.JFMS open reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feline mammary fibroepithelial hyperplasia (FMFH) following a single injection of depot medroxyprogesterone acetate (MPA) was observed in eight intact young queens. The repository compound is marketed as a veterinary product by a local pharmaceutical company with an indication for contraception in cats. The drug was administered according to the recommended doses and injection frequencies. Serum hormone assays performed immediately before neutering and 3 weeks after neutering detected persistently high levels of progesterone suggesting that depot MPA was still exerting its influence. No corpora lutea were found in those cases ruling out ovaries as the main site of progesterone. Immunohistochemistry performed on the hyperplastic mammary glands detected progesterone receptors in the nuclei of ductal cells, and growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the cytoplasm of ductal epithelium. Overdosing should be considered here as the animals received at least 10 mg/kg of depot MPA in a single injection. Progestin-induced local synthesis of GH and IGF-I in mammary epithelial cells is suggested as one of the pathogenic mechanisms involved in the development of FMFH.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.